Results 41 to 50 of about 108,258 (290)
Advanced Healthcare Materials, EarlyView.This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz +9 more
wiley +1 more source
Bicuculline reversibly inhibits mucus secretion.
, 2018 Mucus secretion was analyzed in the presence of 50uM of bicuculline (A) or after changing the media without bicuculline at every 30 min (B). Mucus secretion was restored within 1 hour after removing bicuculline.
Hyo Jung Sim (4876189) +5 more
core +1 more source
Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis
Respiratory Research, 2018 The nervous system mediates key airway protective behaviors, including cough, mucus secretion, and airway smooth muscle contraction. Thus, its involvement and potential involvement in several airway diseases has become increasingly recognized.
Kalina R. Atanasova, Leah R. Reznikov
doaj +1 more source
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A [PDF]
, 2021 TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are associated with inflammatory airway disease and goblet cell metaplasia.
Raquel Centeio +7 more
core +1 more source
Creation of a spatially complex mucus bilayer on an in vitro colon model
Scientific ReportsThe colonic epithelium is comprised of three-dimensional crypts (3D) lined with mucus secreted by a heterogeneous population of goblet cells. In this study, we report the formation of a long-lived, and self-renewing replica of human 3D crypts with a ...
Cecilia Villegas-Novoa +3 more
doaj +1 more source
Advanced Materials, EarlyView.Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou +5 more
wiley +1 more source
mBio, 2017 Intestinal mucus secretion is critical in maintaining mucosal host defense against a myriad of pathogens by preventing direct association with the epithelium.
Steve Cornick +3 more
doaj +1 more source
Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization
Advanced Materials, EarlyView.A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab +8 more
wiley +1 more source
Putative muco-active reagents affecting mucus secretion level.
, 2018 The mucus level in the media upon the treatment of increasing doses of individual chemicals was normalized to those of control embryos and plotted on the graph (left panel, n = 5).
Hyo Jung Sim (4876189) +5 more
core +1 more source