Results 61 to 70 of about 39,694 (292)

Unpacking Changing Multi-Actor and Multi-Level Actor Ties in Transformative Spaces: Insights from a Degraded Landscape, Machubeni, South Africa

Land, 2020
The loss of ecosystem services through land degradation continues to be a significant concern for policymakers and land users around the world. Facilitating collective action among various actors is regarded as imperative in halting land degradation ...
Menelisi Falayi, James Gambiza, Michael Schoon   +2 more
doaj   +1 more source

Customers as decision-makers: strategic environmental assessment in the private sector [PDF]

, 2007
Despite its diversification and global spread, strategic environmental assessment (SEA) remains limited mainly to activities characterised by well-defined planning processes, typically within the public sector.
Byron H., Caratti P., Cole G. A., Dalal-Clayton B., Ertel J., Goulty G., Jay S., Jay S., Jay S., John J., Jones C., Kickert W., Kørnøv L., Marsden S., Marshall R., Marshall R., Nilsson M., Nitz T., Owens S., Partidário M., Partidário M., Partidário M., Schmidt M., Sheate W., Stephen Jay, Thompson J., Thérivel R., Thérivel R., Thérivel R., Verheem R., von Seht H., Wood C.   +31 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Collecting Multi-Actor Family Network Data

Research Data Journal for the Humanities and Social Sciences
Although ‘the family’ is arguably the most fundamental of all social networks, surprisingly little data are available that enable researchers to study the full web of relationships between family members. Mapping family relationships from multiple – preferably ‘all’ – family members’ perspectives enables understanding relational dependencies, such as ...
Vera De Bel, Marijtje A.J. Van Duijn
openaire   +1 more source

Topics in Cement and Concrete Research [PDF]

, 2006
In recent decades, the construction sector has faced many changes. One of these changes is the shift in the role of national government from one-sided practices in which the government was solely responsible for strategic and long-term spatial planning ...
Brouwers, H.J.H.
core   +3 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Managing innovation uncertainties : a user-oriented knowledge typology [PDF]

, 2017
New product development processes are subject to uncertainties. These uncertainties can and should be managed to prevent innovations from failing. Uncertainties or knowledge deficits are addressed by deploying the right approaches, or learning activities
Baccarne, Bastiaan, Conradie, Peter, Herregodts, Aron-Levi, Schuurman, Dimitri   +3 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Cooperative Multi-Agent Reinforcement Learning With Approximate Model Learning

IEEE Access, 2020
In multi-agent reinforcement learning, it is essential for agents to learn communication protocol to optimize collaboration policies and to solve unstable learning problems.
Young Joon Park, Young Jae Lee, Seoung Bum Kim   +2 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source