Results 41 to 50 of about 334,889 (275)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Network Evaluation as a Complex Learning Process
Journal of MultiDisciplinary Evaluation, 2005 The following contribution will explicate, based on an understanding of networking as a reflexive process and on an approach working from a theory of regulation, one set of criteria for the development of evaluation designs in a networking context ...
Susanne Weber
doaj +1 more source
Six Collective Challenges for Sustainability of Almería Greenhouse Horticulture [PDF]
, 2019 Globally, current food consumption and trade are placing unprecedented demand on agricultural systems and increasing pressure on natural resources, requiring tradeoffs between food security and environmental impacts especially given the tension between ...
Alba Patiño, Daniela +19 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
On the right track? : evaluation as a tool to guide spatial transitions [PDF]
, 2015 Spatial developments are becoming more and more non-linear, dynamic and complex with a wide range of possible actors. The awareness of uncertainty in spatial planning is growing and therefore, projects need to integrate a high level of flexibility.
Boelens, Luuk, Pisman, Ann, Terryn, Els
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Applied SciencesArtificial intelligence, particularly machine learning, has revolutionized organizational decision-making processes by assuming many decision responsibilities traditionally allocated to humans.
Silvia Marocco +2 more
doaj +1 more source
Designinig Coordination among Human and Software Agents [PDF]
, 2002 The goal of this paper is to propose a new methodology for designing coordination between human angents and software agents and, ultimately, among software agents. The methodology is based on two key ideas.
Giunchiglia, Fausto +2 more
core
Supporting adaptiveness of cyber-physical processes through action-based formalisms [PDF]
, 2018 Cyber Physical Processes (CPPs) refer to a new generation of business processes enacted in many application environments (e.g., emergency management, smart manufacturing, etc.), in which the presence of Internet-of-Things devices and embedded ICT systems
Marrella, Andrea +2 more
core +1 more source