Results 51 to 60 of about 12,474 (244)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Measuring environmental (in)justices: Insights from a systematic literature review on methodological approaches

iScience
Summary: Environmental (in)justice research uses various conceptual frameworks and methodological approaches, leading to fragmentation across contexts and disciplines.
Jacqueline Loos, Charlotte Gohr, Noelia Zafra-Calvo, Gonzalo Cortés-Capano, Anna Lena Tonninger, Henrik von Wehrden   +5 more
doaj   +1 more source

Participatory foresight for technology assessment

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2018
Technology assessment (TA) frequently uses forward-looking methods  to anticipate socio-technical changes and their corresponding implications  to deduce advice for policy and society.
Mahshid Sotoudeh, Niklas Gudowsky
doaj   +1 more source

France’s Grand Design for Europe and the Elusive Quest for European Sovereignty [PDF]

Political Studies Forum, 2021
In the context of the Liberal International Order crisis amplified by the Trump Administration’s America First doctrine and a retreat of multilateralism, President Macron was emboldened to carry further his vision for a Sovereign Europe (Europe-Puissance)
Marius Mitrache
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Social network analysis of EU flood risk management plans: Case Finland

Journal of Flood Risk Management
Flood risks are increasing in Europe, and the EU Floods Directive is one of the main efforts to implement and harmonize effective flood risk governance and management among member states.
Thomas Banafa, Susa Eräranta, Lasse Peltonen, Marko Keskinen   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Transdisciplinary learning trajectories: developing action and attitude in interplay

Humanities & Social Sciences Communications
Addressing complex societal challenges requires professionals capable of integrating multiple perspectives on problems and possible solutions. This requires crossing disciplinary boundaries and boundaries between science and society.
Annemarie Horn, Marijke W. Visser, Carina A. C. M. Pittens, Eduardo Urias, Marjolein B. M. Zweekhorst, Gerda M. van Dijk   +5 more
doaj   +1 more source