Results 71 to 80 of about 12,474 (244)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A Methodology for the Optimization and Evaluation of Railway Capacity in a Multi-actor Context: The Case Study of the Port of Trieste

, 2021
L’avvento della globalizzazione e della containerizzazione nella seconda metà del secolo scorso ha profondamente alterato la precedente struttura degli scambi commerciali, ponendo una rilevante pressione sui porti. Il ruolo di tali sistemi di trasporto intermodale si è fatto ancor più cruciale a seguito della richiesta dei clienti di fornir loro sia
openaire   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

(Re)Framing Coherence: A Relational Analysis of Social Protection Systems in South Africa and Uganda

Politics and Governance
Coherence is increasingly promoted in international social protection discourse as a remedy for fragmented systems, yet its meaning and application remain unresolved.
Irene Among-Lutz
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Governing the Paradox: Regenerative Coordination in Nigeria’s Energy Transition

Journal of Sustainability
This study developed and tested a system-level account of sustainability coordination in Africa’s extractives-to-energy transition, addressing the absence of a validated construct that captures how multi-actor coordination shapes regenerative outcomes ...
Augustine Okeke
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The power to transform structures: power complexes and the challenges for realising a wellbeing economy

Humanities & Social Sciences Communications
This article draws on different strands of existing scholarship to provide an analytical framework for understanding the barriers to achieving a well-being economy.
Richard Bärnthaler, Andreas Novy, Lea Arzberger, Astrid Krisch, Hans Volmary   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Evaluating Türkiye’s Influence in the Somali Peace Process: Positive or Negative Peace?

Güvenlik Stratejileri Dergisi
This study seeks to examine the role of Türkiye in the peace process in Somalia through the lens of the Peace Studies paradigm. It aims to assess Türkiye’s contributions in light of positive and negative peace concepts developed by Johan Galtung and to ...
Huriye Yıldırım Çinar, Asena Boztaş, N. Ceren Türkmen   +2 more
doaj   +1 more source