Results 71 to 80 of about 334,889 (275)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Measuring environmental (in)justices: Insights from a systematic literature review on methodological approaches

iScience
Summary: Environmental (in)justice research uses various conceptual frameworks and methodological approaches, leading to fragmentation across contexts and disciplines.
Jacqueline Loos, Charlotte Gohr, Noelia Zafra-Calvo, Gonzalo Cortés-Capano, Anna Lena Tonninger, Henrik von Wehrden   +5 more
doaj   +1 more source

LEGITIMASI KEKUASAAN ATAS SEJARAH KERUNTUHAN KERAJAAN MAJAPAHIT DALAM WACANA FOUCAULT

Walisongo: Jurnal Penelitian Sosial Keagamaan, 2016
The history of the collapse of the Majapahit showed the discourse of power. In this context  rule has been supporting a particular version of historical knowledge.
Muhammad Iqbal Birsyada
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The ‘policy mix’ for innovation: rethinking innovation policy in a multi-level, multi-actor context [PDF]

Recent years have seen the emergence, take-up and use of the term 'policy mix' by innovation policy makers and by policy analysts & scholars alike. Imported from economic policy debates, the term implies a focus on the interactions and interdependencies ...
Flanagan, Kieron, Laranja, Manuel, Uyarra, Elvira   +2 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Social network analysis of EU flood risk management plans: Case Finland

Journal of Flood Risk Management
Flood risks are increasing in Europe, and the EU Floods Directive is one of the main efforts to implement and harmonize effective flood risk governance and management among member states.
Thomas Banafa, Susa Eräranta, Lasse Peltonen, Marko Keskinen   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

A governance approach for bim management across lifecycle and supply chains using mixed-modes of information delivery

Journal of Civil Engineering and Management, 2013
Built environment data is of varying nature embedding various forms of sensitivities with potential legal, contractual, intellectual property, and security implications. The paper presents a governance approach for managing multi-actor, multi-discipline,
Yacine Rezgui, Thomas Beach, Omer Rana
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source