Results 61 to 70 of about 334,889 (275)

France’s Grand Design for Europe and the Elusive Quest for European Sovereignty [PDF]

Political Studies Forum, 2021
In the context of the Liberal International Order crisis amplified by the Trump Administration’s America First doctrine and a retreat of multilateralism, President Macron was emboldened to carry further his vision for a Sovereign Europe (Europe-Puissance)
Marius Mitrache
doaj  

Transition towards district heating in belgium : challenges, development and prospect [PDF]

, 2018
Addressing energy shortage problem, is one of the most complex matters that the world is facing nowadays. Within this context, in contrast to northern European countries, the Belgian heat supply sector based on building and dwelling ...
Janssens, Arnold, Prinzie, Tom, Vaillant Rebollar, Julio, Van Marcke, Caroline   +3 more
core   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Multi-agent reinforcement learning for cooperative lane changing of connected and autonomous vehicles in mixed traffic

Autonomous Intelligent Systems, 2022
Autonomous driving has attracted significant research interests in the past two decades as it offers many potential benefits, including releasing drivers from exhausting driving and mitigating traffic congestion, among others. Despite promising progress,
Wei Zhou, Dong Chen, Jun Yan, Zhaojian Li, Huilin Yin, Wanchen Ge   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Change in the Power Elements of the USA between 2001 and 2020 and Its Impact on the Structure of the International System

Güvenlik Stratejileri Dergisi
ower and leadership are a multi-layered and relational process. However, political decision- makers often tend to reduce power to the resources possessed and the results that can be achieved with them.
Demet Güntay Uçar , Burak Samih Gülboy   +1 more
doaj   +1 more source

Participatory foresight for technology assessment

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2018
Technology assessment (TA) frequently uses forward-looking methods  to anticipate socio-technical changes and their corresponding implications  to deduce advice for policy and society.
Mahshid Sotoudeh, Niklas Gudowsky
doaj   +1 more source

Perspective study: governance for C2C [PDF]

, 2010
This perspective study will serve as frame of reference for follow-up activities and exchanges both within and outside the Cradle to Cradle Network (C2CN) and it aims to reflect the current challenges and opportunities associated with implementing a ...
Dewulf, A., Hovelynck, J., Sips, K.
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

The value of theoretical multiplicity for steering transitions towards sustainability [PDF]

, 2009
Transition management, as a theory of directing structural societal changes towards sustainable system innovations, has become a major topic in scientific research over the last years.
Breeman, G.E., Dewulf, A., Pot, W.D., Termeer, C.J.A.M., Werkman, R.A.   +4 more
core   +1 more source