Results 61 to 70 of about 189,667 (292)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Change in the Power Elements of the USA between 2001 and 2020 and Its Impact on the Structure of the International System

Güvenlik Stratejileri Dergisi
ower and leadership are a multi-layered and relational process. However, political decision- makers often tend to reduce power to the resources possessed and the results that can be achieved with them.
Demet Güntay Uçar , Burak Samih Gülboy   +1 more
doaj   +1 more source

Quand les acteurs faibles et absents s’immiscent dans la négociation environnementale

Territoire en Mouvement, 2011
Ecological disturbances force us to inquire, at both global and local levels : how to live together ? or more precisely, how to decide together ? On this aspect, we show that negotiation theories reveal their weaknesses when confronted to absent actors ...
Léa Sebastien
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

At the interface between the formal and informal, the actual and the real: a realist study protocol for governance and accountability practices in urban settings focusing on adolescent sexual and reproductive health and rights

International Journal for Equity in Health, 2022
Background This paper presents the protocol of a study that aims at exploring how different multi-level governance arrangements impact on sexual and reproductive health of adolescents living in informal settlements. The overall objective of this study is
Sara Van Belle
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Measuring environmental (in)justices: Insights from a systematic literature review on methodological approaches

iScience
Summary: Environmental (in)justice research uses various conceptual frameworks and methodological approaches, leading to fragmentation across contexts and disciplines.
Jacqueline Loos, Charlotte Gohr, Noelia Zafra-Calvo, Gonzalo Cortés-Capano, Anna Lena Tonninger, Henrik von Wehrden   +5 more
doaj   +1 more source

France’s Grand Design for Europe and the Elusive Quest for European Sovereignty [PDF]

Political Studies Forum, 2021
In the context of the Liberal International Order crisis amplified by the Trump Administration’s America First doctrine and a retreat of multilateralism, President Macron was emboldened to carry further his vision for a Sovereign Europe (Europe-Puissance)
Marius Mitrache
doaj  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source