Results 81 to 90 of about 334,889 (275)

Transdisciplinary learning trajectories: developing action and attitude in interplay

Humanities & Social Sciences Communications
Addressing complex societal challenges requires professionals capable of integrating multiple perspectives on problems and possible solutions. This requires crossing disciplinary boundaries and boundaries between science and society.
Annemarie Horn, Marijke W. Visser, Carina A. C. M. Pittens, Eduardo Urias, Marjolein B. M. Zweekhorst, Gerda M. van Dijk   +5 more
doaj   +1 more source

Nature-based health initiatives: A governance assessment tool based on indicators

Environmental and Sustainability Indicators
Nature-based health initiatives (NbHIs) are emerging as innovative approaches to promoting human well-being and environmental sustainability. However, a standardised method to evaluate the multi-actor, multi-level, and multi-sector governance required ...
Alessandra Rigo, Laura Secco, Elena Pisani   +2 more
doaj   +1 more source

Towards a more responsible sustainable innovation assessment and management culture in Europe

Engineering Management in Production and Services, 2017
This article presents new concepts and practical approaches resulting from the piloting of CASI-F - a common framework for the assessment and management of sustainable innovation (SI).
Popper Rafael, Popper Monika, Velasco Guillermo   +2 more
doaj   +1 more source

Integrated assessment of biological invasions [PDF]

An assessment of the consequences of biological invasions and of the measures taken against must be at the base of each social decision in this field.
Rauschmayer, Felix
core  

Revisiting Actor Programming in C++

, 2015
The actor model of computation has gained significant popularity over the last decade. Its high level of abstraction makes it appealing for concurrent applications in parallel and distributed systems.
Charousset, Dominik, Hiesgen, Raphael, Schmidt, Thomas C.   +2 more
core   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Organising water: The hidden role of intermediary work [PDF]

, 2009
: The increasingly complex challenges of making water management more sustainable require a critical and detailed understanding of the social organisation of water. This paper examines the hitherto neglected role that 'intermediary' organisations play in
Guy, S, Marvin, S, Medd, W, Moss, T
core   +1 more source