Results 81 to 90 of about 12,747,172 (293)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Consensus Control of Multi-Agent Systems by Intermittent Brownian Noise Stabilization Scheme

IEEE Access
This study explores the consensus of multi-agent systems in the presence of ambient noise using intermittent Brownian noise stabilization. Firstly, the research provides a mathematical explanation of multi-agent systems and intermittent stochastic noise,
Liangyi Cai, Bo Zhang, Mali Xing, Haoyi Mo, Xin Zhou   +4 more
doaj   +1 more source

Security in Multi-Agent Systems

Procedia Computer Science, 2015
AbstractMulti-agent systems become more and more popular due to successful implementations in different fields. However, there is a number of threats that can compromise security of the agent and jeopardize systems security. Therefore, security issues should be taken into consideration during development of multi-agent systems.
Yaqin Hedin, Esmiralda Moradian
openaire   +1 more source

Teams in Multi-Agent Systems [PDF]

, 2007
Multi-agent systems involve agents interacting with each other and the environment and working to achieve individual and group goals. The achievement of group goals requires that agents work together within teams. In this paper we first introduce three philosophical approaches that result from different answers to two key questions.
Jarvis, Bevan., Jarvis, Dennis., Jain, L. C.   +2 more
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Agent-Based Computing and Programming of Agent Systems

, 2006
The concepts of autonomous agent and multi-agent system provide appropriate levels of abstraction for the design, implementation and simulation of many complex, distributed computational systems, particularly those systems open to external participants ...
McBurney, P, Michael Luck, Gonzalez-Palacios, J, Peter McBurney, Luck, M, Jorge Gonzalez-Palacios   +5 more
core   +2 more sources

Modern Trends in Multi-Agent Systems

Future Internet
The term “multi-agent system” is generally understood as an interconnected set of independent entities that can effectively solve complex and time-consuming problems exceeding the individual abilities of common problem solvers [...]
Martin Kenyeres, Ivana Budinská, Ladislav Hluchý, Agostino Poggi   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source