Results 71 to 80 of about 483,640 (297)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Hesitation-Associated Multi-Attribute Decision-Making Method Based on Generalized Interval-Valued Hesitation Fuzzy Weighted Heronian Averaging Operator

Mathematics
In multi-attribute decision making (MADM), complex situations often arise where decision attributes are interval-valued hesitant fuzzy numbers (IVHFNs) and the attributes are interrelated.
Jiayou Shen, Nan Yang, Hejun Liang
doaj   +1 more source

Otomatisasi Keputusan Pemberian Kredit Pensiun Menggunakan Metode Weighted Product [PDF]

, 2019
Otomatisasi Keputusan Pemberian Kredit Pensiun Menggunakan Metode Weighted Product. Dalam memberikan kredit pensiun, PT. Pos Indonesia masih mengalami kesulitan dalam menentukan Pensiun yang berhak atau layak untuk mendapatkan pinjaman kredit, sehingga ...
Naramessakh, K. T. (Kezia), Prianto, C. (Cahyo)   +1 more
core  

Veto values in Group Decision Making within MAUT: aggregating complete rankings derived from dominance intensity measures [PDF]

, 2015
We consider a groupdecision-making problem within multi-attribute utility theory, in which the relative importance of decisionmakers (DMs) is known and their preferences are represented by means of an additive function.
Jiménez Martín, Antonio, Mateos Caballero, Alfonso, Sabio, Pilar   +2 more
core   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Study on Performance Appraisal Method of Vocational Education Teachers using PROMETHEE II [PDF]

, 2011
Evaluating vocational education teachers’ performance is an important link of teaching management and an important guarantee of improving teaching quality.
Jati, Handaru
core  

A method to multi-attribute decision making with picture fuzzy information based on Muirhead mean [PDF]

, 2019
The recently proposed picture fuzzy set (PFS) is a powerful tool for handling fuzziness and uncertainty. PFS is character-ized by a positive membership degree, a neutral membership degree, and a negative membership degree, making it more suitable and ...
Atanassov, Blanco-Mesa, Bonferroni, Cao, Chen, Das, Garg, Guo, Hwang, Jiang, Liao, Liu, Liu, Liu, Liu, Maclaurin, Meng, Merigó, Merigó, Muirhead, Qin, Qin, Son, Sykora, Thong, Tu, Wang, Wang, Wang, Wang, Wang, Wang, Wei, Wei, Xia, Xu, Xu, Yager, Yang, Ye, Yu, Yu, Zadeh, Zhang   +43 more
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Pemilihan Laboran Berprestasi Menggunakan Fuzzy Multi-Attribute Decision Making Simple Additive Weighting [PDF]

, 2016
The Laboratory is an open or closed space managed for practicing activities, testing, calibration using specific equipment and the scientific method. The Laboratory function is very important for the implementation of education, research, or community ...
Rahmawati, R. (Rahmawati), Misriati, T. (Titik)   +1 more
core   +1 more source

Multi-Attribute Decision-Making Model by Applying Grey Numbers

Informatica, 2009
Multi-attribute analysis is a useful tool in many economical, managerial, constructional, etc. problems. The accuracy of performance measures in COPRAS (The multi-attribute COmplex PRoportional ASsessment of alternatives) method is usually assumed to be accurate. This method assumes direct and proportional dependence of the weight and utility degree of
Zavadskas, Edmundas Kazimieras, Kaklauskas, Artūras, Turskis, Zenonas, Tamošaitienė, Jolanta   +3 more
openaire   +3 more sources