Results 81 to 90 of about 8,584,080 (292)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Multi-Attribute Decision-Making Model by Applying Grey Numbers

open access: yesInformatica, 2009
Multi-attribute analysis is a useful tool in many economical, managerial, constructional, etc. problems. The accuracy of performance measures in COPRAS (The multi-attribute COmplex PRoportional ASsessment of alternatives) method is usually assumed to be accurate. This method assumes direct and proportional dependence of the weight and utility degree of
Zavadskas, Edmundas Kazimieras   +3 more
openaire   +3 more sources

A Multi-Attribute Pearson’s Picture Fuzzy Correlation-Based Decision-Making Method

open access: yes, 2019
As a generalization of several fuzzy tools, picture fuzzy sets (PFSs) hold a special ability to perfectly portray inherent uncertain and vague decision preferences.
Dechao Sun   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Multi-Attribute Decision Making with Weighted Description Logics.

open access: yesFLAP, 2017
We introduce a decision-theoretic framework based on Description Logics (DLs), which can be used to encode and solve single stage multi-attribute de- cision problems. In particular, we consider the background knowledge as a DL knowledge base where each attribute is represented by a concept, weighted by a utility value which is asserted by the user ...
Acar, Erman   +4 more
openaire   +3 more sources

A spectrum of compromise aggregation operators for multi-attribute decision making.

open access: yes, 2007
In many decision making problems, a number of independent attributes or criteria are often used to individually rate an alternative from an agent’s local perspective and then these individual ratings are combined to produce an overall assessment. Now, in
Luo, X., Jennings, N. R.
core  

A Distributed Agent-based Decision Support for Cloud Brokering [PDF]

open access: yes, 2014
In goal oriented problems, decision-making is a crucial aspect aiming at enhancing the ability to make decisions by full autonomous, or supervised software agents.
Amato, Alba, Venticinque, Salvatore
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

MULTI-CRITERIA ANALYSIS OF FACTORS USE LEVEL: THE CASE OF WATER FOR IRRIGATION [PDF]

open access: yes
In this paper we present a methodology to analyse input use in the agricultural sector. The novelty of the theoretical model explained is that it has been developed considering a multi-criteria environment.
Gomez-Limon, Jose Antonio   +2 more
core   +2 more sources

Multi-Attribute Group-Decision on a Construction Diversion Scheme for Hydropower Projects Based on Perception Utility

open access: yesEnergies, 2018
The multi-attribute and group-decision problem in the selection of a construction diversion scheme for large hydropower projects often involves multi-decision subjects and schemes.
Dawei Liu, Zhigen Hu, Wencheng Guo
doaj   +1 more source

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