Results 41 to 50 of about 171,881 (262)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Integrated FEM-Multibody Co-Simulation of Additively Manufactured Hip Prosthesis containing cracks
Fracture and Structural IntegrityThe increase in life expectancy and attention to the quality of life of elderly people spurred the need, in the last decades, to increase the capabilities of medical and surgical techniques.
Roberto Di Bona +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Analysis of free-field pressure sensor laying mechanism design in anti-shock test of warship
Zhongguo Jianchuan Yanjiu, 2019 [Objectives]In order to solve the problem of free-field pressure sensor laying in dynamic anti-shock test of warship,[Methods]based on the theory of computational multi-body dynamics and fluid dynamics,the laying mechanism of free-field pressure sensor ...
Gao Haopeng
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Numerical study of railway wheel wear on roller rigs
Nihon Kikai Gakkai ronbunshu, 2020 The dynamic behavior of railway vehicle is often tested by roller rig equipment and this test is very useful. However, it is known that contact condition on roller rig is different from the case that wheels run on rail.
Satoshi HARA +3 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
A Vector Bond Graph Method of Dynamics Modeling for Planar Multi-body Systems with Grooved Sheave
Jixie chuandong, 2017 In order to increase the reliability and efficiency of the dynamics modeling and analysis for complex planar multi-body systems containing grooved sheave,the corresponding vector bond graph procedure is proposed.
Wang Zhongshuang +2 more
doaj
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source