Results 51 to 60 of about 171,881 (262)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Wear Prediction and Chaos Identification of Rigid Flexible Coupling Multi-Link Mechanisms with Clearance

Lubricants
Traditional revolute clearance joints assume that the shape of the contact surface of the joint is regular and ignores the effects of wear, which reduces the prediction accuracy of dynamics models.
Yonghao Jia, Kai Meng, Shuai Jiang, Jing Kang   +3 more
doaj   +1 more source

Flapping Wing Multi-body Dynamic Simulation

Procedia Engineering, 2015
AbstractThe previous study on modelling of the flapping wing micro air vehicle used to concentrate on thecomplicated aerodynamic computation and the research on the dynamic simulation is often constrained to frequently use the oversimplified 6-degree of freedom (DOF) rigid body equations. However, the motion of the wing is seriously interfered with the
Jingyang, Zhong, Bifeng, Song, Jin, Wang
openaire   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Development of Real-time Remote Driving Simulator based on Multi-body Dynamics [PDF]

한국정밀공학회지
Autonomous robots are commonly operated on rough roads. Thus, it is essential to predict their dynamic characteristics. Even though it is possible to use real hardware to acquire a robot’s dynamic characteristics, this requires a significant amount of ...
Suhyun Park, Jeonghyun Sohn, Xiangqian Zhu   +2 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Establishment of the Virtual Prototyping of Angular Transmission Error of RV Reducer based on Multi-body Dynamics Simulation

Jixie chuandong, 2018
In order to study the influence of modification of cycloid gear and bearing clearance on angular transmission error of RV reducer,based on the multi-body dynamics simulation technology,multi-body contact between gears is established by combining with the
Chang Anquan, Zhang Yinghui, He Weidong, Wang Xiaoyu   +3 more
doaj  

Development of an integrated engineering education model using multi-body closed system modeling, computational analysis, and signal processing analysis

Mechanics & Industry
In this study, free high-level programming languages, GNU Octave and Python, are used to model the mechanical part simulating the periodic signal generated in the mechanical system and to link with the signal processing unit that analyzes the generated ...
Park Yonghu
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Dynamic Modeling and Flight Performance Analysis for Large Bionic Ornithopters Considering Structural Flexibility

Nanjing Hangkong Hangtian Daxue Xuebao
The flapping wing of large bionic ornithopters （LBOs） has obvious flexible deformation during the flapping motion， which is difficult for aerodynamic analysis.
XU Hui, PAN Erzhen, XU Wenfu, HUANG Hailin   +3 more
doaj   +1 more source