Results 71 to 80 of about 171,881 (262)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Coupled Modeling of Sea Surface Launch Flow and Multi-Body Motion

Journal of Marine Science and Engineering
To simulate the launching process of missile complex flow, movement, and constraint states, a multifield coupling model is put forward based on a computational fluid dynamics (CFD) method.
Haotian Liu, Shangming Li, Shilong Hou, Debin Fu   +3 more
doaj   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Optimization of Potato Planter Soil Lifting Device Based on TRIZ Theory

Agriculture
Aiming at the problems of low soil cover and serious wear and tear of transmission parts in the soil lifting device of potato planters, this paper carries out innovative optimization design of its key parts based on TRIZ theory.
Hua Zhang, Hongling Li, Wei Sun, Hui Li, Xiaolong Liu, Gang Sun, Yonggang Lu, Yangzhou Chen, Wei Xing   +8 more
doaj   +1 more source

Construction of seated passenger model on high speed railway vehicle by multi-body dynamics

Mechanical Engineering Journal, 2016
In recent years, the speed of express train has been raised by the improvement of technology about the vehicle, truck and electric. However, the speedup of railway vehicle caused high frequency vibration, and thus riding comfort is deteriorated by the ...
Kou HISANO, Takayoshi KAMADA, Ryohei SHIMAMUNE, Shinichi HASEGAWA, Kousuke OOTAKI   +4 more
doaj   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Numerical Study on the Sensitive Wavelength and Amplitude Management of Track Irregularities in Monorail Systems

Buildings
Track irregularity is one of the principal excitations that induces coupled vibrations in vehicle–bridge systems. Understanding the sensitive wavelength of track irregularities is critical for the evaluation and management of track conditions.
Hong Zhang, Pengjiao Wang, Chen Chen, Yanqiang Ji, Shiqi Wei, Boyou Guan, Zhiqiang Liu, Jie Zhang   +7 more
doaj   +1 more source

Effect of Hip Joint Center on Multi-body Dynamics and Contact Mechanics of Hip Arthroplasty for Crowe IV Dysplasia. [PDF]

Orthop Surg, 2022
Gao Y, Chai W, An Z, Chen X, Dong Z, Zhang Z, Jin Z.   +6 more
europepmc   +1 more source

Multi-body Dynamics Simulation by Parallel Computers.

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C, 1999
The purpose of this study is to establish a technique of solving large scale problems associated with multi-body dynamics simulations and to break through the limitations imposed by traditional methods. It is necessary to compute on a computer, which is fast and has larger memory, for multibody analysis of LSS (Large Space Structure).
OKAMOTO, Osamu, OHKAMI, Yoshiaki, KAMIMURA, Heihachiro, YOSHIDA, Masahiro, ISHIHARA, Keisuke   +4 more
openaire   +2 more sources

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source