Results 31 to 40 of about 1,347,779 (299)

Compiler Optimization on Instruction Scheduling for a Specialized Real-Time Floating Point Soft-Core Processor

Advances in Electrical and Computer Engineering, 2019
This paper presents the authors' research in the field of specialized optimizing assembly language compilers for embedded real-time soft-core processor systems on FPGAs.
KIRCHHOFF, M., WAGNER, L., FENGLER, W.
doaj   +1 more source

A FPGA-Based, Granularity-Variable Neuromorphic Processor and Its Application in a MIMO Real-Time Control System

Sensors, 2017
Artificial Neural Networks (ANNs), including Deep Neural Networks (DNNs), have become the state-of-the-art methods in machine learning and achieved amazing success in speech recognition, visual object recognition, and many other domains.
Zhen Zhang, Cheng Ma, Rong Zhu
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

A Fast Implementation of Minimum Spanning Tree Method and Applying it to Kruskal’s and Prim’s Algorithms

Sukkur IBA Journal of Computing and Mathematical Sciences, 2017
In last decade, application developers attained improved performances by merely employing the machines based on higher-clocked processors. However, in 2003 multi-core processors emerged and eradicated the old processor manufacturing technology based on ...
Badri Munier, Muhammad Aleem, Muhammad Arshad Islam, Muhammad Azhar Iqbal, Waqar Mehmood   +4 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Multi-Core optimization technology of unstructured grid based on Sunway TaihuLight [PDF]

Jisuanji gongcheng, 2019
In order to solve discrete memory access problem of unstructured grid in high performance computing,this paper proposes a general multi-core optimization algorithm according to the architecture features of the heterogeneous multi-core processor SW26010 ...
NI Hong, LIU Xin
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source