Results 71 to 80 of about 1,489,032 (375)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Optimizing Large Language Models on Multi-Core CPUs: A Case Study of the BERT Model
Applied SciencesThe BERT model is regarded as the cornerstone of various pre-trained large language models that have achieved promising results in recent years. This article investigates how to optimize the BERT model in terms of fine-tuning speed and prediction ...
Lanxin Zhao, Wanrong Gao, Jianbin Fang
doaj +1 more source
Evaluating and Optimizing IP Lookup on Many core Processors [PDF]
, 2012 International audienceIn recent years, there has been a growing interest in multi/many core processors as a target architecture for high performance software router.
Guan, Hongtao +3 more
core +3 more sources
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Realization and Application of Shenwei Simultaneous Multithreading Functional Simulator [PDF]
Jisuanji gongcheng, 2016 imultaneous Multithreading(SMT) allows irrelevant instructions execute synchronously from multiple threads.It achieves the combination of Thread-level Parallelism(TLP) and Instruction-level Parallelism(ILP),enhances the performance of processor further ...
CHEN Weijian,GUO Yong,YIN Fei
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
ESAIR: A Behavior-Based Robotic Software Architecture on Multi-Core Processor Platforms
International Journal of Automation and Smart Technology, 2013 This paper introduces an Embedded Software Architecture for Intelligent Robot systems (ESAIR) that addresses the issues of parallel thread executions on multi-core processor platforms. ESAIR provides a thread scheduling interface to improve the execution
Chin-Yuan Tseng +2 more
doaj +1 more source