Results 71 to 80 of about 1,234,846 (256)
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Investigation on Quantitative Structure-Activity Relationships of 1,3,4 Oxadiazole Derivatives as Potential Telomerase Inhibitors [PDF]
, 2018 The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/164022/article, DOI : 10.2174/1570163815666180724113208. © 2018 Bentham ScienceA series of 1,3,4-oxadiazole derivatives with significant broad-spectrum anticancer ...
Almerico, Anna Maria +2 more
core +2 more sources
FEBS Open Bio, EarlyView.This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc +8 more
wiley +1 more source
A Multi-Criteria Decision Framework for Animal Welfare Policy [PDF]
Policy decisions aimed at improving farm animal welfare involve balancing several competing objectives. Not only do such decisions involve tradeoffs between social, ethical, economic and welfare considerations, animal welfare itself is a multi ...
Bicknell, Kathryn, Hellstrom, J.
core +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Business: Theory and Practice, 2017 Lithuania has had a significant reform path in the last twenty-five years like other communist bloc countries during the intense changes in the world. Changes and transformations took place in various areas including social security system.
Lina Novickytė +1 more
doaj +1 more source
Participation in multicriteria decision support - the case of conflicting water allocation in the Spree River basin [PDF]
This discussion paper presents the Integrated Methodological Approach for participatory multi-criteria decision support under uncertainty (IMA), which emerged from the debates about participation, multi-criteria analysis (MCA) and benefit-cost analysis ...
Karkuschke, Matthias +2 more
core
A multi-criteria decision analysis tool to support electricity planning [PDF]
, 2012 A Multi-Criteria Decision Analysis (MCDA) tool was designed to support the evaluation of different electricity production scenarios. The MCDA tool is implemented in Excel worksheet and uses information obtained from a mixed integer optimization model ...
Araújo, Maria Madalena Teixeira de +2 more
core
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
EnergiesDefining compensatory interactions among criteria is a critical yet often subjective step in multi-criteria decision analysis (MCDA). To address this gap, this study proposes a novel model centered around the Inter-Criteria Compensation Index (ICCI ...
Maiquiel Schmidt de Oliveira +2 more
doaj +1 more source