Results 81 to 90 of about 46,954 (256)

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Genetic basis of antimicrobial drug resistance in clinical isolates of Salmonella enterica serotype hadar from a Spanish region

, 2005
The genetic bases of antimicrobial drug resistance (R) of 79 Salmonella enterica serotype Hadar clinical isolates (recovered during 1995-2001 in a Spanish region) was investigated.
Mendoza,M.C., Martinez,N., Gonzalez-Hevia,M.A., Guerra,B., Rodicio,M.R.   +4 more
core   +1 more source

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, EarlyView.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Multi-drug-resistance (MDR) in septoria leaf blotch

, 2015
Context: Multidrug resistance (MDR) is a common trait developed by many organisms tocounteract chemicals and/or drugs. The basic MDR mechanism relies on an overexpressedefflux transport system that actively expulses the toxic agent. In fungi, MDR has beenextensively studied in Saccharomyces cerevisiae, but also plant pathogenic fungi, e.g.,Botrytis ...
Omrane, Selim, Audeon, Colette, Ignace, Amandine, Duplaix, Clémentine, Sghyer, Hind, Aouini, Lamia, Kema, Gert, Walker, Anne Sophie, Fillinger, Sabine   +8 more
openaire   +3 more sources

Uncovering Key Characteristics of Antibacterial Peptides through Machine Learning

Macromolecular Rapid Communications, EarlyView.
Machine‐learning (ML) techniques using random forest classification models revealed key characteristics that predict effective antimicrobial peptides (AMPs) targeting Gram‐negative bacteria, Gram‐positive bacteria, and mycobacteria. The ideal cLogP (<$ < $−6) and net‐charge (≤+4) threshold was the same for all three targets with variations in the ...
Jooyoung Roh, Cyrille Boyer, Priyank V. Kumar   +2 more
wiley   +1 more source

Mechanistic Studies Of Drug Resistance Conferred By An ABC Transporter DrrAB

, 2015
Multi-drug resistance (MDR) has become a serious clinical problem for both cancer and infectious disease treatment. One of the leading causes of MDR is the drug efflux mediated by the ATP-binding cassette (ABC) super-family of proteins which are found ...
Zhang, Han
core   +1 more source

Blunted blades: new CRISPR-derived technologies to dissect microbial multi-drug resistance and biofilm formation

mSphere
The spread of multi-drug-resistant (MDR) pathogens has rapidly outpaced the development of effective treatments. Diverse resistance mechanisms further limit the effectiveness of our best treatments, including multi-drug regimens and last line-of-defense ...
Christopher Gager, Ana L. Flores-Mireles
doaj   +1 more source

Analysis of Eurasian Stone curlew (Burhinus oedicnemus) microbial flora reveals the presence of multi-drug resistant pathogens in agro-pastoral areas of Sicily (Italy)

Heliyon, 2020
Spread of multi-drug resistant (MDR) bacteria in natural environments pose a risk to human and animal health. Wild birds are considered to be reservoirs of human pathogens and vectors of antimicrobial resistance distribution in the environment.
Maria Foti, Rosario Grasso, Vittorio Fisichella, Antonietta Mascetti, Manuel Andrea Zafarana, Marco Colnaghi, Maria Grasso, Maria Teresa Spena   +7 more
doaj   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

Patterns of drug resistance in cases of smear positive pulmonary tuberculosis in Giza and Cairo governorates

Egyptian Journal of Chest Disease and Tuberculosis, 2012
Background: Pulmonary tuberculosis is a major cause of morbidity and mortality World Wide, resulting in the greatest number of deaths due to any other single infectious agent. Drug resistance threatens global tuberculosis control efforts.
K. Aid Sobhy, S. Elawady, S. Abdel Latef, A. Abou Zeid, M. Said   +4 more
doaj   +1 more source