Frontiers in Oncology, 2021 Ovarian cancer is the most lethal gynaecologic tumor, with which multi-drug resistance as the major therapeutic hindrance. Heat shock protein 90 (Hsp90) has been involved in cancer malignant behaviors.
Lan Yin +8 more
doaj +3 more sources
The challenges of multi-drug-resistance in hepatology [PDF]
Journal of Hepatology, 2016 Antimicrobial resistance has become a major global public health security problem that needs coordinated approaches at regional, national and international levels. Antibiotic overuse and the failure of control measures to prevent the spread of resistant bacteria in the healthcare environment have led to an alarming increase in the number of infections ...
Javier Fernández +2 more
exaly +3 more sources
Strategies to Combat Multi-Drug Resistance in Tuberculosis [PDF]
Accounts of Chemical Research, 2021 "Drug resistance is an unavoidable consequence of the use of drugs; however, the emergence of multi-drug resistance can be managed by accurate diagnosis and tailor-made regimens."Antimicrobial resistance (AMR), is one of the most paramount health perils that has emerged in the 21st century.
Vinayak Singh, Kelly Chibale
exaly +3 more sources
Multi-label classification for multi-drug resistance prediction of Escherichia coli
Computational and Structural Biotechnology Journal, 2022 Antimicrobial resistance (AMR) is a global health and development threat. In particular, multi-drug resistance (MDR) is increasingly common in pathogenic bacteria.
Yunxiao Ren +7 more
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Correlation Analysis Between Multi-Drug Resistance Phenotype and Virulence Factor Expression of Clinical Pseudomonas aeruginosa [PDF]
Current Issues in Molecular BiologyPseudomonas aeruginosa (PA), as a common pathogen of nosocomial infections, has been experiencing an increasing rate of drug resistance with the widespread use and abuse of antimicrobial drugs.
Wenli Xu +11 more
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Glutathione‐Sensitive Photosensitizer–Drug Conjugates Target the Mitochondria to Overcome Multi‐Drug Resistance in Cancer [PDF]
Advanced ScienceMulti‐drug resistance (MDR) is a major cause of cancer therapy failure. Photodynamic therapy (PDT) is a promising modality that can circumvent MDR and synergize with chemotherapies, based on the generation of reactive oxygen species (ROS) by ...
Weiguo Song +13 more
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Autophagy and Transporter-Based Multi-Drug Resistance [PDF]
Cells, 2012 All the therapeutic strategies for treating cancers aim at killing the cancer cells via apoptosis (programmed cell death type I). Defective apoptosis endow tumor cells with survival. The cell can respond to such defects with autophagy.
Zhe-Sheng Chen +3 more
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Anthracyclines, proteasome activity and multi-drug-resistance [PDF]
BMC Cancer, 2005 Background P-glycoprotein is responsible for the ATP-dependent export of certain structurally unrelated compounds including many chemotherapeutic drugs. Amplification of P-glycoprotein activity can result in multi-drug resistance and is a common cause of
Pajonk Frank +2 more
doaj +5 more sources
Modeling spatial evolution of multi-drug resistance under drug environmental gradients. [PDF]
PLoS Computational BiologyMulti-drug combinations to treat bacterial populations are at the forefront of approaches for infection control and prevention of antibiotic resistance.
Tomas Ferreira Amaro Freire +3 more
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Multi-Drug Resistance in Bacterial Genomes-A Comprehensive Bioinformatic Analysis. [PDF]
Int J Mol Sci, 2023 Domingues CPF +3 more
europepmc +2 more sources