Results 1 to 10 of about 752,738 (184)

Chaperonin GroEL/GroES over-expression promotes multi-drug resistance in E. coli following exposure to aminoglycoside antibiotics [PDF]

Frontiers in Microbiology, 2016
Antibiotic resistance is an increasing challenge to modern healthcare. Aminoglycoside antiobiotics cause translation corruption and protein misfolding and aggregation in Escherichia coli.
Lise eGoltermann, Menachem Viktor Sarusie, Thomas eBentin   +2 more
doaj   +8 more sources

Correlation Analysis Between Multi-Drug Resistance Phenotype and Virulence Factor Expression of Clinical Pseudomonas aeruginosa [PDF]

Current Issues in Molecular Biology
Pseudomonas aeruginosa (PA), as a common pathogen of nosocomial infections, has been experiencing an increasing rate of drug resistance with the widespread use and abuse of antimicrobial drugs.
Wenli Xu, Runcheng Zhou, Jingwei Pan, Zhuangcong Liu, Xuyu Huang, Yueqiao Lin, Nan Li, Kecan Chen, Wenbo Sun, Yi Deng, Anping Yang, Xin Chen   +11 more
doaj   +2 more sources

Glutathione‐Sensitive Photosensitizer–Drug Conjugates Target the Mitochondria to Overcome Multi‐Drug Resistance in Cancer [PDF]

Advanced Science
Multi‐drug resistance (MDR) is a major cause of cancer therapy failure. Photodynamic therapy (PDT) is a promising modality that can circumvent MDR and synergize with chemotherapies, based on the generation of reactive oxygen species (ROS) by ...
Weiguo Song, Hekai Yang, Ying Wang, Shuzhen Chen, Wenda Zhong, Qian Wang, Wenshuo Ding, Guangzhao Xu, Chen Meng, Ying Liang, Zhe‐Sheng Chen, Shuhua Cao, Liuya Wei, Fahui Li   +13 more
doaj   +2 more sources

Modeling spatial evolution of multi-drug resistance under drug environmental gradients. [PDF]

PLoS Computational Biology
Multi-drug combinations to treat bacterial populations are at the forefront of approaches for infection control and prevention of antibiotic resistance.
Tomas Ferreira Amaro Freire, Zhijian Hu, Kevin B Wood, Erida Gjini   +3 more
doaj   +2 more sources

Heat Shock Protein 90 Triggers Multi-Drug Resistance of Ovarian Cancer via AKT/GSK3β/β-Catenin Signaling

Frontiers in Oncology, 2021
Ovarian cancer is the most lethal gynaecologic tumor, with which multi-drug resistance as the major therapeutic hindrance. Heat shock protein 90 (Hsp90) has been involved in cancer malignant behaviors.
Lan Yin, Yuhan Yang, Wanglong Zhu, Yu Xian, Zhengyu Han, Houyi Huang, Liaotian Peng, Kun Zhang, Ye Zhao   +8 more
doaj   +1 more source

The impact of COVID-19 on the tuberculosis control activities in Addis Ababa

The Pan African Medical Journal, 2021
The first COVID-19 case was reported in Ethiopia on 13th March 2020 and series of announcements of set of measures, proclamation and directives have been enacted to fight the coronavirus pandemic.
Negussie Wodajo Beyene, Alemu Lakew Sitotaw, Ben Tegegn, Kidist Bobosha   +3 more
doaj   +1 more source

Linezolid use for the treatment of multidrug-resistant tuberculosis, TB centers of excellence, United States, 2013–2018

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2021
Background: In 2019, the World Health Organization released guidelines reflecting major changes in multidrug-resistant tuberculosis (MDR-TB) management—prioritizing fluoroquinolones, bedaquiline, and linezolid (LZD) while de-emphasizing previously ...
Ashley McDowell, Michelle Haas, Barbara Seaworth, John W. Wilson, Amee Patrawalla, Connie Haley, Mike Lauzardo, Miko de Bruyn, Neela D. Goswami   +8 more
doaj   +1 more source

Optimal drug synergy in antimicrobial treatments. [PDF]

PLoS Computational Biology, 2010
The rapid proliferation of antibiotic-resistant pathogens has spurred the use of drug combinations to maintain clinical efficacy and combat the evolution of resistance.
Joseph Peter Torella, Remy Chait, Roy Kishony   +2 more
doaj   +1 more source

Lead optimisation of dehydroemetine for repositioned use in malaria [PDF]

, 2020
Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the multi ...
Abubaker, M, Bryce, RA, Burusco, KK, Fernández-Álvaro, E, Gutnov, A, Matthews, H, Nirmalan, NJ, Panwar, P, Wilkinson, JA   +8 more
core   +3 more sources

Drug Resistance Reversal Potential of Nanoparticles/Nanocomposites via Antibiotic’s Potentiation in Multi Drug Resistant P. aeruginosa

Nanomaterials, 2021
Bacteria employ numerous resistance mechanisms against structurally distinct drugs by the process of multidrug resistance. A study was planned to discover the antibacterial potential of a graphene oxide nanosheet (GO), a graphene oxide–zinc oxide ...
Pratima Pandey, Rajashree Sahoo, Khusbu Singh, Sanghamitra Pati, Jose Mathew, Avinash Chandra Pandey, Rajni Kant, Ihn Han, Eun-Ha Choi, Gaurav Raj Dwivedi, Dharmendra K. Yadav   +10 more
doaj   +1 more source