Negligible risk of inducing resistance in Mycobacterium tuberculosis with single-dose rifampicin as post-exposure prophylaxis for leprosy [PDF]
, 2016 Post-exposure prophylaxis (PEP) for leprosy is administered as one single dose of rifampicin (SDR) to the contacts of newly diagnosed leprosy patients. SDR reduces the risk of developing leprosy among contacts by around 60 % in the first 2-3 years after ...
Anthony, Richard +13 more
core +6 more sources
Increased expression of a microRNA correlates with anthelmintic resistance in parasitic nematodes [PDF]
, 2017 Resistance to anthelmintic drugs is a major problem in the global fight against parasitic nematodes infecting humans and animals. While previous studies have identified mutations in drug target genes in resistant parasites, changes in the expression ...
Bartley, David +13 more
core +2 more sources
Pneumonia Caused by Klebsiella spp. in 46 Horses. [PDF]
, 2015 BackgroundKlebsiella spp. are implicated as a common cause of bacterial pneumonia in horses, but few reports describe clinical presentation and disease progression.Hypothesis/objectivesTo describe the signalment, clinicopathologic data, radiographic and ...
Aleman, M +7 more
core +1 more source
Effect of Different Media on the Bactericidal Activity of Colistin and on the Synergistic Combination With Azidothymidine Against mcr-1-Positive Colistin-Resistant Escherichia coli [PDF]
, 2020 Antimicrobial susceptibility testing (AST) performed according to defined guidelines is important to identify resistance and to predict the clinical success or failure of specific antibiotic therapy.
Coates, A +4 more
core +1 more source
Journal of Infection in Developing Countries, 2017 Erysipelothrix rhusiopathiae infection occurs in animals and humans. It manifests primarily as a local skin lesion, which can be treated with antibiotics. Systemic infection with E. rhusiopathiae is rare, with low occurrence of bacteremia. We describe a
Zhenning Liu, Min Zhao
doaj +1 more source
Systematic functional identification of cancer multi-drug resistance genes
Genome Biology, 2020 Background Drug resistance is a major obstacle in cancer therapy. To elucidate the genetic factors that regulate sensitivity to anti-cancer drugs, we performed CRISPR-Cas9 knockout screens for resistance to a spectrum of drugs.
Man-Tat Lau +14 more
doaj +1 more source
Drug resistance characteristics of Salmonella isolated from diarrheal patients in Shunyi, Beijing
Zhongguo shipin weisheng zazhi, 2021 ObjectiveTo study the drug resistance characteristics of Salmonella isolated from diarrheal patients in Shunyi, Beijing.MethodsCollected stool samples of diarrheal patients in Shunyi, Beijing 2013-2018.
JIN Hongwu +5 more
doaj +1 more source
Frontiers in Microbiology, 2023 Due to the long-term and irrational use of antibiotics for the prevention and control of bacterial diseases in aquaculture, antibiotic resistance genes have become a new source of pollution in aquatic products.
Zihui Gao +6 more
doaj +1 more source
Mutators can drive the evolution of multi-resistance to antibiotics.
PLoS Genetics, 2023 Antibiotic combination therapies are an approach used to counter the evolution of resistance; their purported benefit is they can stop the successive emergence of independent resistance mutations in the same genome.
Danna R Gifford +7 more
doaj +1 more source
High-throughput Binding Affinity Calculations at Extreme Scales [PDF]
, 2018 Resistance to chemotherapy and molecularly targeted therapies is a major factor in limiting the effectiveness of cancer treatment. In many cases, resistance can be linked to genetic changes in target proteins, either pre-existing or evolutionarily ...
Balasubramanian, Vivek +7 more
core +3 more sources