Results 31 to 40 of about 752,857 (303)

Multiscale modelling of cancer progression and treatment control : the role of intracellular heterogeneities in chemotherapy treatment [PDF]

, 2015
Cancer is a complex, multiscale process involving interactions at intracellular, intercellular and tissue scales that are in turn susceptible to microenvironmental changes.
Chaplain, Mark Andrew Joseph, Powathil, Gibin   +1 more
core   +1 more source

Determinan pola resistensi pasien Multi-Drug Resistant Tuberculosis (MDRTB) : Studi Multi-Center di Jember, Indonesia

Indonesian Journal of Pharmaceutical Education
Drug-resistant, particularly multidrug resistance tuberculosis (MDRTB), is an emerging problem due to its low success rate of treatment outcomes. Most MDRTB in Indonesia was rifampicin resistant (RRTB).
Intan Wahidah, Khoiriyatul Muhlishoh Arwi, Ika Norcahyanti, Ema Rachmawati, Ika Puspita Dewi, Dhita Evi Aryani, Afifah Machlaurin   +6 more
doaj   +1 more source

Antibiotic Resistance in Bacteria—A Review

Antibiotics, 2022
Background: A global problem of multi-drug resistance (MDR) among bacteria is the cause of hundreds of thousands of deaths every year. In response to the significant increase of MDR bacteria, legislative measures have widely been taken to limit or ...
Renata Urban-Chmiel, Agnieszka Marek, Dagmara Stępień-Pyśniak, Kinga Wieczorek, Marta Dec, Anna Nowaczek, Jacek Osek   +6 more
doaj   +1 more source

A genomic and evolutionary approach reveals non-genetic drug resistance in malaria [PDF]

, 2014
Background: Drug resistance remains a major public health challenge for malaria treatment and eradication. Individual loci associated with drug resistance to many antimalarials have been identified, but their epistasis with other resistance mechanisms ...
Broadbent, Kate M, Clish, Clary B, Deik, Amy A, Desai, Michael M, Herman, Jonathan D, Mazitschek, Ralph, Moss, Eli L, Neafsey, Daniel E, Ribacke, Ulf, Rice, Daniel P, Silterra, Jacob, Wirth, Dyann F   +11 more
core   +1 more source

Characteristics and treatment outcomes of patients with multi-drug-resistant tuberculosis at Abbassia Chest Hospital

The Egyptian Journal of Bronchology
Background Multi-drug-resistant tuberculosis (MDR-TB) remains a significant health concern. This study analyzes patients admitted to Abbassia Chest Hospital, focusing on their characteristics, drug resistance patterns, treatment outcomes, and risk ...
Ibrahim Mostafa Mohamed Nofal, Hesham Atef AbdelHalim, Ashraf Abbass Almaraghy, Amr Mohammed Awad, Mohamed Ali Farrag   +4 more
doaj   +1 more source

Autophagy and Transporter-Based Multi-Drug Resistance

Cells, 2012
All the therapeutic strategies for treating cancers aim at killing the cancer cells via apoptosis (programmed cell death type I). Defective apoptosis endow tumor cells with survival. The cell can respond to such defects with autophagy.
Zhe-Sheng Chen, Kurt Degenhardt, Dong-Mei Zhang, Priyank Kumar   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Anthracyclines, proteasome activity and multi-drug-resistance

BMC Cancer, 2005
Background P-glycoprotein is responsible for the ATP-dependent export of certain structurally unrelated compounds including many chemotherapeutic drugs. Amplification of P-glycoprotein activity can result in multi-drug resistance and is a common cause of
Pajonk Frank, McBride William H, Fekete Mirela R   +2 more
doaj   +1 more source

Case Study on Multi-Drug Resistance Tuberculosis in Grobogan, Central Java [PDF]

, 2017
Background: Tuberculosis is a communicable disease that remains a major public health issue worldwide. Tuberculosis epidemics have become a primary public health concern for the last few decades.
Ahmad, Z. (Zahir), Joebagyo, H. (Hermanu), Utomo, G. C. (Gunawan)   +2 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source