Results 31 to 40 of about 7,245,224 (256)
Mutators can drive the evolution of multi-resistance to antibiotics.
PLoS Genetics, 2023 Antibiotic combination therapies are an approach used to counter the evolution of resistance; their purported benefit is they can stop the successive emergence of independent resistance mutations in the same genome.
Danna R Gifford +7 more
doaj +1 more source
Indonesian Journal of Pharmaceutical EducationDrug-resistant, particularly multidrug resistance tuberculosis (MDRTB), is an emerging problem due to its low success rate of treatment outcomes. Most MDRTB in Indonesia was rifampicin resistant (RRTB).
Intan Wahidah +6 more
doaj +1 more source
Drug resistance in metastatic castration-resistant prostate cancer: an update on the status quo [PDF]
, 2022 Prostate cancer (PCa) is a leading cause of cancer-related morbidity and mortality in men globally. Despite improvements in the diagnosis and treatment of PCa, a significant proportion of patients with high-risk localized disease and all patients with ...
Wakimian, Kevork +8 more
core +1 more source
The Egyptian Journal of BronchologyBackground Multi-drug-resistant tuberculosis (MDR-TB) remains a significant health concern. This study analyzes patients admitted to Abbassia Chest Hospital, focusing on their characteristics, drug resistance patterns, treatment outcomes, and risk ...
Ibrahim Mostafa Mohamed Nofal +4 more
doaj +1 more source
Autophagy and Transporter-Based Multi-Drug Resistance
Cells, 2012 All the therapeutic strategies for treating cancers aim at killing the cancer cells via apoptosis (programmed cell death type I). Defective apoptosis endow tumor cells with survival. The cell can respond to such defects with autophagy.
Zhe-Sheng Chen +3 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
VIM-1, VIM-2, and GES-5 Carbapenemases Among Pseudomonas aeruginosa Isolates at a Tertiary Hospital in Istanbul, Turkey. [PDF]
, 2017 Worldwide increase in carbapenem resistance and transferable carbapenemases are significant challenges in treatment of Pseudomonas aeruginosa infections. In this study, investigation of carbapenemase production in carbapenem-resistant P.
Otlu, Barış +4 more
core +1 more source
Pharmacological modulation and manipulation of cancer drug resistance [PDF]
, 2010 The aim of this project was to investigate pharmacological methods of overcoming resistance in cancer. Novel compounds, targeted therapies and non-steroidal anti-inflammatory drugs (NSAIDs) were examined for their potential to modulate and manipulate ...
Devery, Aoife
core +2 more sources
Anthracyclines, proteasome activity and multi-drug-resistance
BMC Cancer, 2005 Background P-glycoprotein is responsible for the ATP-dependent export of certain structurally unrelated compounds including many chemotherapeutic drugs. Amplification of P-glycoprotein activity can result in multi-drug resistance and is a common cause of
Pajonk Frank +2 more
doaj +1 more source
Antibiotic Resistance in Bacteria—A Review
Antibiotics, 2022 Background: A global problem of multi-drug resistance (MDR) among bacteria is the cause of hundreds of thousands of deaths every year. In response to the significant increase of MDR bacteria, legislative measures have widely been taken to limit or ...
Renata Urban-Chmiel +6 more
doaj +1 more source