Results 111 to 120 of about 36,032 (319)

Recombinant anticoccidial vaccines - a cup half full? [PDF]

, 2017
Eimeria species parasites can cause the disease coccidiosis, most notably in chickens. The occurrence of coccidiosis is currently controlled through a combination of good husbandry, chemoprophylaxis and/or live parasite vaccination; however, scalable ...
Ahmad, Arnott, Awad, Bafundo, Blake, Blake, Blake, Brothers, Brown, Chapman, Chapman, Chapman, Chapman, Chapman, Chapman, Chapman, Chapman, Chen, Clark, Clark, Cornelissen, Cosentino, Crane, Dalloul, Damer P. Blake, Ding, Ding, Djemai, Du, Eckford, Fiona M. Tomley, Fischbach, Fluit, Gedik, Gowen, Hedhli, Hoan, Huang, Iván Pastor-Fernández, Jahn, Jang, Jang, Jenkins, Jenkins, Jenkins, Jiang, Joyner, Karlsson, Keestra, Klotz, Koblansky, Konjufca, Kundu, Kvicerova, Labbe, Lai, Lassen, Lee, Li, Li, Lillehoj, Liu, Long, Marugan-Hernandez, Matthew J. Nolan, McDonald, McDonald, Min, Naciri, Nolan, Peek, Peek, Plattner, Pogonka, Reid, Ruff, Rugarabamu, Salazar Gonzalez, Sathish, Schaap, Shah, Sharman, Shen, Shirley, Shirley, Smith, Song, Song, Song, Song, Song, Song, Song, Subramanian, Sun, Takala, Tang, Tomley, Tomley, Tomley, Vermeulen, Vrba, Wallach, Wang, Wang, Williams, Williams, Williams, Williams, Williams, Witcombe, Wu, Xu, Xu, Yin, Yin, Yun, Zhang, Zhang, Zimmermann   +119 more
core   +1 more source

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

Advanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak, Shivananda Kandagalla, Ramesh Sistla   +2 more
wiley   +1 more source

Immunoinformatics Design and In Vivo Immunogenicity Evaluation of a Conserved CTL Multi-Epitope Vaccine Targeting HPV16 E5, E6, and E7 Proteins

Vaccines
Human papillomavirus type 16 (HPV16) infection is responsible for more than 50% of global cervical cancer cases. The development of a vaccine based on cytotoxic T-lymphocyte (CTL) epitopes is a promising strategy for eliminating pre-existing HPV ...
Ni Guo, Zhixin Niu, Zhiling Yan, Weipeng Liu, Lei Shi, Chuanyin Li, Yufeng Yao, Li Shi   +7 more
doaj   +1 more source

Fibronectin Fibers Progressively Lose Their Tension in Invasive Human Breast Carcinoma while Being Tensed in DCIS and Healthy Breast Tissue

Advanced Science, EarlyView.
Extracellular matrix remodeling is crucial in cancer progression. Using a peptide to probe the tension of ECM fibers, it was found that Fibronectin fibers gradually lose tension as human breast carcinoma progresses, while their tension is maintained in ductal carcinoma in situ (DCIS), the non‐invasive precursor of breast cancer. This loss of tension is
Arnaud Miéville, Charlotte M. Fonta, Cornelia Leo, Lucine Christe, Jörg Goldhahn, Gad Singer, Viola Vogel   +6 more
wiley   +1 more source

Influenza and memory T cells : how to awake the force [PDF]

, 2016
Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals.
Glezen, Hartshorn, Hufford, Jin, Jordan, Luo, Mosmann, Razvi, Topham, Topham, Topham, Von Andrian, Wijburg   +12 more
core   +3 more sources

Microneedles at the Forefront of Next Generation Theranostics

Advanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang, Yuan Yang, Jiaqi Zhang, Hanrui Zhang, Qian Wang, Shengmei Ma, Pengfei Zhao, Zhou Li, Yuxin Liu   +8 more
wiley   +1 more source

The tumor-associated antigen RHAMM (HMMR/CD168) is expressed by monocyte-derived dendritic cells and presented to T cells [PDF]

, 2016
We formerly demonstrated that vaccination with Wilms' tumor 1 (WT1)-loaded autologous monocyte-derived dendritic cells (mo-DCs) can be a well-tolerated effective treatment in acute myeloid leukemia (AML) patients.
Anguille, Sebastien, Berneman, Zwi N, Bonte, Sarah, Goossens, Herman, Heirman, Carlo, Kerre, Tessa, Peeters, Marc, Smits, Evelien LJ, Stein, Barbara MH, Thielemans, Kris, Van den Bergh, Johan M. J., Van Tendeloo, Viggo FI, Willemen, Yannick   +12 more
core   +1 more source

Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer

Advanced Science, EarlyView.
This review compares clinical outcomes, translational progress, and global funding trends across cancer phototherapies—photodynamic, photothermal, and photoimmunotherapy—and conventional immunotherapy. It highlights differences in treatment efficacy, clinical trial status, financial investment, and regulatory challenges, providing a comprehensive ...
Deepak S. Chauhan, Kun Shao, Roopa Hebbandi Nanjundappa, Daniel‐Jiajun Yu, Marianne Stanford, Huile Gao, Channakeshava Sokke Umeshappa   +6 more
wiley   +1 more source

Bioactivity-guided mass spectral net working reveals a new set of allbicidin derivatives from Xanthomonas albilineans [PDF]

, 2016
Albicidin is produced by the sugarcane pathogenic bacterium Xanthomonas albilineans and is a potent antibiotic specifically targeting the bacterial DNA gyrase with an IC50 value in the nanomolar range.
Cociancich, Stéphane, Dang, Tam, Dorrestein, Pieter C., Pesic, Alexander, Petras, Daniel, Royer, Monique, Süssmuth, Roderich   +6 more
core   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

Advanced Science, EarlyView.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li, Ya‐Li Zhang, Tong Jin, Zhaokui Jin, Mengliang Zhu, Guangchao Qing, Jinchao Zhang, Zhisen Wang, Yan Mu, Jin Li, Qian Hua, Xing‐Jie Liang   +11 more
wiley   +1 more source