Results 91 to 100 of about 3,636,379 (304)

Structural basis of development of multi-epitope vaccine against Middle East respiratory syndrome using in silico approach

, 2018
Sukrit Srivastava,1,2 Mohit Kamthania,1,3 Soni Singh,1 Ajay K Saxena,2 Nishi Sharma1 1Department of Biotechnology, Mangalayatan University, Aligarh, India; 2Molecular Medicine Lab, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India ...
Srivastava S, Kamthania M, Sharma N, Singh S, Saxena AK   +4 more
core  

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Immunoinformatics-driven design of a multi-epitope vaccine against nipah virus: A promising approach for global health protection

Journal of Genetic Engineering and Biotechnology
This study focuses on developing a multi-epitope vaccine against the highly pathogenic Nipah virus using immunoinformatics. It aims to design a vaccine targeting the viral nucleoprotein to elicit robust immune responses.
Muhammad Aqib Shabbir, Ammara Amin, Ammarah Hasnain, Ayesha Shakeel, Ambreen Gul   +4 more
doaj   +1 more source

A Computational Assay to Design an Epitope-Based Peptide Vaccine Against Saint Louis Encephalitis Virus

, 2013
Saint Louis encephalitis virus, a member of the flaviviridae subgroup, is a culex mosquito-borne pathogen. Despite severe epidemic outbreaks on several occasions, not much progress has been made with regard to an epitope-based vaccine designed for Saint ...
Md. Anayet Hasan, Mehjabeen Hossain, Md. Jibran Alam, Anayet Hasan Md., Jibran Alam Md.   +4 more
core   +1 more source

Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations

Advanced Science, EarlyView.
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford, Matthew Tamasi, Elena Di Mare, Adam J. Gormley   +3 more
wiley   +1 more source

Design and evaluation of a multi-epitope subunit vaccine against human norovirus using an immunoinformatics approach [PDF]

Osong Public Health and Research Perspectives
Objectives This study aimed to identify safe, conserved, and highly immunogenic epitopes from all proteins of human-infecting norovirus (NoV) and to design a multi-epitope subunit vaccine construct from these epitopes using an immunoinformatics approach.
Zxcy L. Nonog, Edward C. Banico, Ma. Easter V. Sajo, Pablo V. Serrano, Fredmoore L. Orosco   +4 more
doaj   +1 more source

A polyepitope DNA vaccine targeted to Her-2/ErbB-2 elicits a broad range of human and murine CTL effectors to protect against tumor challenge.

, 2007
A cDNA vaccine (pVax1/pet-neu) was designed to encode 12 different Her-2/ErbB-2-derived, HLA-A*0201-restricted dominant and high-affinity heteroclitic cryptic epitopes.
Lemonnier, François A, A. M. Jackson, Alimandi, Maurizio, Jordan Marrocco, Cencioni, Giulia, S. Chouaib, Stephanie Graf-Dubois, Graf-Dubois, S, Chouaib, S, A. Scardino, Hüseyin Firat, Graf-Dubois, Stephanie, Steven G. Smith, K. Kosmatopoulos, Kosmatopoulos, K., Smith, SG, Antonio Scardino, Roberto Bei, Giulia Cencioni, S. G. Smith, G. Cencioni, P. Correale, François A. Lemonnier, Kosmatopoulos, Kostas, Faure, Olivier, Firat, Hüseyin, Olivier Faure, Firat, H, Lemonnier, FA, Jackson, AM, Kostas Kosmatopoulos, Chouaib, Salem, Correale, P, Andrew Michael Jackson, Cusi, MG, Maria Grazia Cusi, Alimandi, M, Correale, Pierpaolo, Bei, Roberto, M. G. Cusi, Marrocco, Jordan, S. Graf Dubois, F. A. Lemonnier, Smith, Steven G, Scardino, A, Cencioni, G, Pierpaolo Correale, Graf Dubois, S, Salem Chouaib, Faure, O, Marrocco, J, Kosmatopoulos, K, Scardino, Antonio, Cusi, Maria Grazia, J. Marrocco, Bei, R, R. Bei, Maurizio Alimandi, H. Firat, O. Faure, Jackson, Andrew Michael, MARROCCO J., FIRAT H., ALIMANDI M., LEMONNIER F. A., GRAF-DUBOIS S., BEI R., FAURE O., JACKSON A. M., CHOUAIB S., KOSMATOPOULOS K., CENCIONI G., CORREALE P., SCARDINO A., SMITH S. G., CUSI M. G.   +75 more
core   +1 more source

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Structural vaccinology considerations for in silico designing of a multi-epitope vaccine

Infection, Genetics and Evolution, 2018
Multi-epitope peptide vaccines, as a kind of fusion proteins, usually possess a string-of-beads structure, consisting of several peptidic epitopes, probably adjuvants and linkers. Very numerous options are possible in selecting the order of different segments and linkers.
Manica, Negahdaripour, Navid, Nezafat, Mahboobeh, Eslami, Mohammad Bagher, Ghoshoon, Eskandar, Shoolian, Sohrab, Najafipour, Mohammad Hossein, Morowvat, Ali, Dehshahri, Nasrollah, Erfani, Younes, Ghasemi   +9 more
openaire   +2 more sources

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source