Results 131 to 140 of about 3,636,379 (304)

In silico prediction of multi-epitope vaccine candidates against Mycobacterium leprae

Current Biomedicine
Background Leprosy, also known as Hansen's disease, is an infectious disease caused by Mycobacterium leprae. Despite ongoing efforts to control the disease, leprosy remains a global health concern, with Indonesia ranking third in the world for the ...
Almas Shabrina, Asep Iin Nur Indra, Sonny Feisal Rinaldi, Fusvita Merdekawati   +3 more
doaj   +1 more source

Advances of computational methods enhance the development of multi-epitope vaccines

Briefings in Bioinformatics
Abstract Vaccine development is one of the most promising fields, and multi-epitope vaccine, which does not need laborious culture processes, is an attractive alternative to classical vaccines with the advantage of safety, and efficiency.
Yiwen Wei, Tianyi Qiu, Yisi Ai, Yuxi Zhang, Junting Xie, Dong Zhang, Xiaochuan Luo, Xiulan Sun, Xin Wang, Jingxuan Qiu   +9 more
openaire   +2 more sources

Primary and booster immune responses to SA14-14-2 Japanese encephalitis vaccine in Korean infants

, 1999
Attenuated SA14-14-2 Japanese encephalitis (JE) vaccine has been administered safely and effectively to more than 100 million children in China since 1988 and recently, licensure of the vaccine in Korea has been sought.
박민수
core   +1 more source

Hyper‐Intense Tumor Peripheral Accumulation of Antibody‐Conjugated Iron Oxide Nanoparticles can Enable Breast Cancer Detection by Magnetic Particle Imaging

Advanced Science, EarlyView.
Tumor‐associated inflammation retains antibody‐targeted or non‐specific antibody conjugated nanoparticles within the tumor microenvironment. Magnetic Particle Imaging (MPI) enables non‐invasive detection and differentiation of tumors from other organs, owing to higher nanoparticle retention by inflammatory cells in the tumor periphery.
Preethi Korangath, Hayden Carlton, Theresa Wong, Sean Healy, Toby Sanders, Mason Song, Patrick W. Goodwill, Cordula Grüttner, Kathleen Gabrielson, Robert Ivkov   +9 more
wiley   +1 more source

Immunoinformatics‐Based Multi‐Epitope Vaccine Design Against P. falciparum‐Causing Malaria: A Computational Approach

Health Science Reports
Background and Aim Malaria is an infectious disease that affects people in Africa, and other parts of the world by the millions. Despite the effectiveness of artemisinin‐based combination therapies against the disease, current findings on possible ...
Amma Aboagyewa Larbi, Caleb Mensah, Rebecca Korankye, Andrew Appiah Darkwah, Esther Boakye Agyemang, Isaac Yao Ayikpah, Alexander Kwarteng   +6 more
doaj   +1 more source

Development of a multi-epitope vaccine targeting Taenia solium extracellular vesicle proteome through immunoinformatics analysis

In Silico Research in Biomedicine
Helminth infections implicate a socioeconomic impact by affecting 1.5 billion people, accounting to 24% of the global population suffering from helminth infections.
Parul Mehra, Amit Prasad
doaj   +1 more source

Design of a multi-epitope vaccine candidate against Vibrio cholerae

Scientific Reports
Cholera is an acute, highly contagious diarrheal disease caused by the gram-negative bacterium Vibrio cholerae, typically contracted through contaminated water or food. Without timely treatment, cholera can lead to severe dehydration and death. The COVID-19 pandemic has underscored the critical importance of vaccine development, emphasizing the need ...
Fatemeh Nouri Koupaei, Armity Kiumarsy, Mohammad Mahdi Feizi, Zohreh Vajdi, Seyed Edalat Pishkar, Mahsa Alem, Esmaeil Roohparvar Basmenj   +6 more
openaire   +3 more sources

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Multi-Epitope DC Vaccines with Melanoma Antigens for Immunotherapy of Melanoma

Vaccines
Background/Objectives: The revolution for the treatment of melanoma came with the approval of checkpoint blockade antibodies. However, a substantial proportion of patients show primary or secondary resistance to this type of immunotherapy, indicating the need for alternative therapeutic strategies.
Athanasios Seretis, Lukas Amon, Christoph H. Tripp, Giuseppe Cappellano, Florian Hornsteiner, Sophie Dieckmann, Janine Vierthaler, Daniela Ortner-Tobider, Markus Kanduth, Rita Steindl, Louis Boon, Joke M. M. den Haan, Christian H. K. Lehmann, Diana Dudziak, Patrizia Stoitzner   +14 more
openaire   +4 more sources

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

Advanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge, John S. Fossey, David Gonzalez Calatayud, Stephen E. Flower, Sabrina Wang, Hanna Aitessaid, Melita Tvardauskaite, Julia Dudzic, Max Jewell, Charareh Pourzand, Stanley W. Botchway, David Gurevich, Tony D. James, Sofia I. Pascu   +13 more
wiley   +1 more source