Results 141 to 150 of about 3,636,379 (304)

A comprehensive strategy for the development of a multi-epitope vaccine targeting Treponema pallidum, utilizing heat shock proteins, encompassing the entire process from vaccine design to in vitro evaluation of immunogenicity

Frontiers in Microbiology
BackgroundTreponema pallidum, the causative spirochete of syphilis, is primarily transmitted through sexual contact and has emerged as a significant global health concern.
Jing Jiang, Jing Jiang, Linglan Xu, Linglan Xu, Xuefeng Wang, Ming Wang, Youde Cao, Ranhui Li, Kang Zheng, Xian Wu   +9 more
doaj   +1 more source

Immunoinformatics-based design of a multi-epitope vaccine for Marburg virus

Journal of Biomolecular Structure and Dynamics
Marburg viruses (MARV) are negative-stranded RNA viruses belonging to filoviridae family. This virus causes severe haemorrhagic fever in humans and non-human primates, with a high fatality rate. Currently, there are no vaccines or drugs have been approved to induce productive immunity or control viral infection.
Esakkimuthu Thangamariappan, Praseetha Sivakumar, Shakti Chandra Vadhana Marimuthu, Selvaraj Kunjiappan, Krishnan Sundar   +4 more
openaire   +2 more sources

Optimized Multi-Epitope Norovirus Vaccines Induce Robust Humoral and Cellular Responses in Mice

Background: Norovirus GII.4 is a major global health threat, yet no licensed vaccines exist due to the virus’s rapid evolution and high mutation rates.
Dai, Wenlong, Xun Chen, Chen, Xun, Jiang, Nan, Xing, Ziyan, Cao, Peifang, Feng, Ercui, Ercui Feng, Nan Jiang, Qing Xu, Wenlong Dai, Luyao Ji, Ziyan Xing, Ji, Luyao, Xu, Qing, Peifang Cao   +15 more
core   +1 more source

Epitope-driven common subunit vaccine design against H. pylori strains

, 2018
The developing potent vaccine is a pre-emptive strategy to tackle drug abuses and maladies of multidrug-resistant Helicobacter pylori strains. Ongoing vaccine studies are being conducted, however, development is in its infancy as ineffective vaccine ...
Ravina Madhulitha Nalamolu (6115376), Chiranjeevi Pasala (6115373), Aparna R. Bitla (6115379), Sudheer Kumar Katari (5877476), Umamaheswari Amineni (6161747), Chandra Sekhar Reddy Chilamakuri (7270157)   +5 more
core   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

Reverse vaccinology and immunoinformatics approach to design a chimeric epitope vaccine against Orientia tsutsugamushi

Heliyon
Scrub typhus is a vector-borne infectious disease caused by Orientia tsutsugamushi and it is reportedly associated with up to 20 % of hospitalized cases of febrile illnesses.
Anutee Dolley, Himanshu Ballav Goswami, Dikshita Dowerah, Upalabdha Dey, Aditya Kumar, Vanlal Hmuaka, Rupak Mukhopadhyay, Debasree Kundu, George M. Varghese, Robin Doley, Ramesh Chandra Deka, Nima D. Namsa   +11 more
doaj   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Multi-epitope Melanoma Peptide Vaccine [PDF]

, 2020
openaire   +1 more source

Immunoinformatic-driven design of a multi-epitope vaccine against Helicobacter pylori

Biochemistry and Biophysics Reports
Helicobacter pylori (H. pylori) is present in the gastric mucosa of approximately half of the global population and is classified as a definitive type I carcinogen. Developing a logical and effective vaccine against H. pylori remains a critical need.
Rahimi-Farsi, Nasim, Bostanian, Fatemeh, Ahmadi, Khadijeh, Zangooie, Alireza, Sedighi, Mahsa, Shahbazi, Behzad, Mottaghi-Dastjerdi, Negar   +6 more
openaire   +3 more sources

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source