Results 121 to 130 of about 79,223 (384)

The genome of the protozoan parasite Cystoisospora suis and a reverse vaccinology approach to identify vaccine candidates [PDF]

, 2017
Vaccine development targeting protozoan parasites remains challenging, partly due to the complex interactions between these eukaryotes and the host immune system.
Aliaga-Leyton, Altenhoff, Anja Joachim, Aruna Shrestha, Bhopale, Blake, Blake, Blum, Bradford, Burset, Bärbel Ruttkowski, Cantarel, Claus Vogl, Conesa, Cui, Damer P. Blake, de Oliveira Lopes, Dlugonska, Elsheikha, Emanuelsson, Fiona Tomley, Flower, Gabner, Gajria, Gharahdaghi, Goodswen, Goodswen, Goodswen, Goodswen, Hassan, Hehl, Hiszczynska-Sawicka, Horton, Jackson, Jenkins, Jimenez, Joachim, Jones, Jongert, Kall, Kim, Kissinger, Korf, Kurtz, Larsen, Lillehoj, Lim, Lindsay, Loytynoja, Martens, Matrajt, McAllister, Meyer, Min, Monney, Monney, Mortazavi, Mundt, Myhre, Nam, Nicola Palmieri, Nishikawa, Ogedengbe, Parra, Petersen, Pizza, Ramaprasad, Reichel, Samarasinghe, Sato, Schulz, Schwarz, Schwarz, Shevchenko, Shrestha, Sonnhammer, Stanisic, Stanke, Stephen, Templeton, Thorvaldsdottir, Tomas Beck, Trapnell, Williams, Worliczek, Worliczek, Worliczek, Xiang, Zhu   +88 more
core   +2 more sources

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Reverse vaccinology-based multi-epitope COVID-19 vaccine targeting SARS-CoV-2 structural and non-structural proteins induces immune responses in mice

Vaccine: X
Vaccination is effective to end pandemics, including the Coronavirus disease-2019 (COVID-19). However, the evolution of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) which is characterized by the emergence of the virus variants has a great
Azzania Fibriani, Nicholas Yamahoki, Annisa Meliana Shani, Afifatur Rofiqoh, Agust Leo Fany Siregar, Cynthia Gunawan, Carola Giovanni Danira Mayorga, Tommy Octavianus Soetrisno Tjia, Husna Nugrahapraja, Ernawati Arifin Giri-Rachman, Marselina Irasonia Tan   +10 more
doaj   +1 more source

Design of immunogenic and effective multi-epitope DNA vaccines for melanoma [PDF]

Cancer Immunology, Immunotherapy, 2011
Plasmid DNA vaccination is an attractive way to elicit T cell responses against infectious agents and tumor cells. DNA constructs can be designed to contain multiple T cell epitopes to generate a diverse immune response to incorporate numerous antigens and to reduce limitations due to MHC restriction into a single entity.
Hyun-Il, Cho, Esteban, Celis
openaire   +2 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Active immunisation of mice with GnRH lipopeptide vaccine candidates: importance of T helper or multi-dimer GnRH epitope [PDF]

, 2014
Active immunisation against gonadotropin releasing hormone (GnRH) is a potential alternative to surgical castration. This study focused on the development of a GnRH subunit lipopeptide vaccine.
Chang, Cheng-Hung, D'Occhio, Michael J., Goodwin, Daryn, Mansfeld, Friederike M., Simerska, Pavla, Toth, Istvan, Varamini, Pegah   +6 more
core   +1 more source

An Immunoinformatic strategy to develop new Mycobacterium tuberculosis multi-epitope vaccine

International Journal of Peptide Research and Therapeutics, 2022
Abstract Mycobacterium tuberculosis causes a life-threatening disease known as tuberculosis (TB). In 2021, tuberculosis was the second cause of death after COVID-19 among infectious diseases. Latent life cycle and development of multidrug resistance in one hand and lack of an effective vaccine in another hand have made TB a global health issue.
openaire   +2 more sources

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Chagas Disease Diagnostic Applications: Present Knowledge and Future Steps [PDF]

, 2016
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating illness of major significance throughout Latin America and an emergent threat to global public health.
Balouz, Virginia, Buscaglia, Carlos Andres, Fernandez Aguero, Maria Jose   +2 more
core   +1 more source