Results 121 to 130 of about 36,032 (319)

An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy

Advanced Science, EarlyView.
This study develops a dimeric T cell receptor engager protein specific for tumor KRAS‐G12V mutation. The engager proteins are capable of mediating the formation of synapse between T cell and tumor cell and demonstrate substantial tumor suppression efficacy.
Keke Ma, Jie Wang, Min Jiang, Juanhua He, Fangyang Li, Dan Lu, Chao Su, Yan Chai, Wenjing Jin, Yu Chen, Catherine W.H. Zhang, Xiaopeng Ma, Hui Tan, George F. Gao, Shuguang Tan   +14 more
wiley   +1 more source

Immunoinformatics approach to designing a multi-epitope vaccine against Saint Louis Encephalitis Virus

Informatics in Medicine Unlocked, 2021
The Saint Louis Encephalitis Virus (SLEV) is one of the causes of a rare, inflammatory condition of the brain tissues known as encephalitis. Belonging to the Flaviviridae family, SLEV can cause severe, detrimental repercussions on the central nervous ...
Md. Shakhawat Hossain, Mohammad Imran Hossan, Shagufta Mizan, Abu Tayab Moin, Farhana Yasmin, Al-Shahriar Akash, Shams Nur Powshi, A.K Rafeul Hasan, Afrin Sultana Chowdhury   +8 more
doaj  

Bridging One Health: Computational design of a multi-epitope messenger RNA vaccine for cross-species immunization against Nipah virus [PDF]

International Journal of One Health
Background and Aim: Nipah virus (NiV) poses a threat to human and animal health, particularly swine, which serve as primary vectors for human transmission.
Edward C. Banico, Ella Mae Joy S. Sira, Lauren Emily Fajardo, Fredmoore L. Orosco   +3 more
doaj   +1 more source

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Advanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu   +37 more
wiley   +1 more source

Patent Landscape of Helminth Vaccines and Related Technologies [PDF]

, 2013
Executive Summary This report focuses on patent landscape analysis of technologies related to vaccines targeting parasitic worms, also known as helminths.
Burke, Rayna, Cavicchi, Jon R., Kowalski, Stanley P., Michaud-King, Jillian, Schroeder, John   +4 more
core   +1 more source

An Anisotropic Gold‐Palladium Heterostructured Nanosystem for Synergistically Overcoming Radioresistance and Enhancing Melanoma Radioimmunotherapy

Advanced Science, EarlyView.
A multifunctional anisotropic Au‐Pd heterostructured nanosystem is developed that incorporates a plasmonically enhanced Au‐Pd core, with a shell composed of a biodegradable, Mn‐doped targeting peptide. The nanosystem integrates photothermal, radiotherapeutic, and immunomodulatory functions.
Cheng Chen, Yuqi Huang, Wandong Wang, Minghao Chao, Weiguo Sun, Yinghui Kong, Guan Jiang, Yong Gao, Fenglei Gao   +8 more
wiley   +1 more source

A comprehensive strategy for the development of a multi-epitope vaccine targeting Treponema pallidum, utilizing heat shock proteins, encompassing the entire process from vaccine design to in vitro evaluation of immunogenicity

Frontiers in Microbiology
BackgroundTreponema pallidum, the causative spirochete of syphilis, is primarily transmitted through sexual contact and has emerged as a significant global health concern.
Jing Jiang, Jing Jiang, Linglan Xu, Linglan Xu, Xuefeng Wang, Ming Wang, Youde Cao, Ranhui Li, Kang Zheng, Xian Wu   +9 more
doaj   +1 more source

Candidate multi-epitope vaccines in aluminium adjuvant induce high levels of antibodies with predefined multi-epitope specificity against HIV-1 [PDF]

, 2000
Jian Ding, Yun Lu, Yinghua Chen
openalex   +1 more source

Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B

Advanced Science, EarlyView.
Kaposi's sarcoma‐associated herpesvirus (KSHV) causes severe cancers without effective treatments. This study presents an atomic model of KSHV's critical infection protein, gB, revealing a unique structure shared with related herpesviruses like Epstein‐Barr virus (EBV). The structural similarity highlights vulnerable targets for antibodies, guiding the
Xin‐Yan Fang, Cong Sun, Chu Xie, Bing‐Zhen Cheng, Zheng‐Zhou Lu, Ge‐Xin Zhao, Sen‐Fang Sui, Mu‐Sheng Zeng, Zheng Liu   +8 more
wiley   +1 more source

Evaluation of protective effect of multi-epitope DNA vaccine encoding six antigen segments of Toxoplasma gondii in mice [PDF]

, 2009
Shan Liu, Lin Shi, Yanbin Cheng, Gui-xiang Fan, Huixun Ren, Yukang Yuan   +5 more
openalex   +1 more source