Results 131 to 140 of about 36,032 (319)

Fragment Autoantigens Stimulated T‐Cell‐Immunotherapy (FAST) as a Fast Autologous Cancer Vaccine

Advanced Science, EarlyView.
A personalized whole tumor cell vaccine (FAST) is developed to address immunosuppressive tumor microenvironments and genomic instability‐driven heterogeneity. Irradiation and cryoablation‐treated tumor cells generate fragmented antigens (FAs) that activate broad‐spectrum antigen presentation via upregulated immunogenic cell death, MHC‐I, and damage ...
Yuan Li, Huiqin Chen, Qiaofeng Shen, Yingshuang Liu, Pingping Li, Yuqi Ma, Yugang Wang, Shengkai Li, Xueqing Yan, Liyu Liu, Jianwei Shuai, Min Wu, Qi Ouyang, Feng‐Ming (Spring) Kong, Gen Yang   +14 more
wiley   +1 more source

A bioinformatics approach to introduce novel multi-epitope vaccines against Acinetobacter baumannii retrieved from immunogenic extracellular loops of outer membrane proteins

Informatics in Medicine Unlocked, 2022
Increasing antibiotic resistance of Acinetobacter baumannii highlights the urgent need to develop an effective vaccine to combat it. Despite all efforts, no approved vaccine against this bacterium is on the market, and attempts are underway to find ...
Maryam Meskini, Narjes Noori Goodarzi, Sepideh Fereshteh, Negin Bolourchi, Amir Mirzaie, Farzad Badmasti   +5 more
doaj  

VennVax, a DNA-prime, peptide-boost multi-T-cell epitope poxvirus vaccine, induces protective immunity against vaccinia infection by T cell response alone [PDF]

, 2010
Leonard Moise, R. Mark L. Buller, Jill Schriewer, Jinhee Lee, Sharon E. Frey, David B. Weiner, William Martin, Anne S. De Groot   +7 more
openalex   +1 more source

Machine Learning‐Enhanced Nanoparticle Design for Precision Cancer Drug Delivery

Advanced Science, EarlyView.
Machine Learning (ML) is revolutionizing cancer nanomedicine by optimizing nanoparticle (NP) design and drug delivery. This review summarizes ML applications across all stages of NP drug delivery, along with a discussion of ongoing challenges and future directions.
Qingquan Wang, Yujian Liu, Chenchen Li, Bin Xu, Shidang Xu, Bin Liu   +5 more
wiley   +1 more source

Current strategies, advances, and challenges in multi-epitope subunit vaccine development for African swine fever virus

Veterinary Integrative Sciences
African Swine Fever (ASF), a highly contagious and lethal viral disease affecting swine populations, presents a critical global threat with no approved vaccine.
Ella Mae Joy S. Sira, Edward C. Banico, Lauren Emily Fajardo, Nyzar Mabeth O. Odchimar, Alea Maurice Simbulan, Fredmoore L. Orosco   +5 more
doaj   +1 more source

Therapeutic Protection Against H. pylori Infection in Mongolian Gerbils by Oral Immunization With a Tetravalent Epitope-Based Vaccine With Polysaccharide Adjuvant

Frontiers in Immunology, 2019
Urease is an effective target for design of a therapeutic epitope vaccine against Helicobacter pylori (H. pylori). In our previous studies, an epitope vaccine CTB-UE containing Th and B epitopes from H.
Le Guo, Le Guo, Le Guo, Dantong Hong, Shue Wang, Fan Zhang, Feng Tang, Tao Wu, Yuankui Chu, Hongpeng Liu, Meng He, Hua Yang, Runting Yin, Kunmei Liu, Kunmei Liu   +14 more
doaj   +1 more source

Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma [PDF]

, 2012
Surasak Phuphanich, Christopher J. Wheeler, Jeremy Rudnick, Mia Mazer, Hongqian Wang, Miriam Nuño, Jaime Richardson, Xuemo Fan, Jianfei Ji, Ray M. Chu, James Bender, Elma S. Hawkins, Chirag G. Patil, Keith L. Black, John S. Yu   +14 more
openalex   +1 more source

“Confined Eutectic” Strategy for Visual Refrigeration Responsive Fluorescent Materials with Easy Preparation and Multi‐Color Tunability

Advanced Science, EarlyView.
A new strategy of “confined eutectic” is proposed to achieve fluorochromic materials that can readout refrigeration temperature with naked‐eye. It leverages changes in the crystallinity of the confined eutectics in nano/micro‐domains to regulate the aggregation and dispersion states of fluorophores.
Jifang Zhao, Jiahui Du, Tianyou Qin, Sean Xiao‐An Zhang, Lan Sheng   +4 more
wiley   +1 more source

In silico prediction of multi-epitope vaccine candidates against Mycobacterium leprae

Current Biomedicine
Background Leprosy, also known as Hansen's disease, is an infectious disease caused by Mycobacterium leprae. Despite ongoing efforts to control the disease, leprosy remains a global health concern, with Indonesia ranking third in the world for the ...
Almas Shabrina, Asep Iin Nur Indra, Sonny Feisal Rinaldi, Fusvita Merdekawati   +3 more
doaj   +1 more source

Immunological features and efficacy of a multi-epitope vaccine CTB-UE against H. pylori in BALB/c mice model [PDF]

, 2013
Le Guo, Runting Yin, Kunmei Liu, Xiaobo Lv, Yonghong Li, Xiangguo Duan, Yuankui Chu, Tao Xi, Yingying Xing   +8 more
openalex   +1 more source