Results 161 to 170 of about 36,032 (319)

A Canine-Directed Chimeric Multi-Epitope Vaccine Induced Protective Immune Responses in BALB/c Mice Infected with Leishmania infantum [PDF]

, 2020
Maria Agallou, Maritsa Margaroni, Stathis D. Kotsakis, Evdokia Karagouni   +3 more
openalex   +1 more source

In silico design of Mycobacterium tuberculosis multi-epitope adhesin protein vaccines

Heliyon
Mycobacterium tuberculosis (Mtb) adhesin proteins are promising candidates for subunit vaccine design. Multi-epitope Mtb vaccine and diagnostic candidates were designed using immunoinformatic tools. The antigenic potential of 26 adhesin proteins were determined using VaxiJen 2.0. The truncated heat shock protein 70 (tnHSP70), 19 kDa antigen lipoprotein
Koobashnee Pillay, Thamsanqa E. Chiliza, Sibusiso Senzani, Balakrishna Pillay, Manormoney Pillay   +4 more
openaire   +3 more sources

Human Cervix Chip: A Preclinical Model for Studying the Role of the Cervical Mucosa and Microbiome in Female Reproductive Health

BioEssays, EarlyView.
The microfluidic Cervix Chip is an in vitro model of the human cervix lined by cervical epithelium interfaced with stromal cells cultured under dynamic flow that represents a new preclinical platform for studying mucosal immunity, host‐microbiome interactions, infections, fertility, and pregnancy health.
Zohreh Izadifar, Anna Stejskalova, Aakanksha Gulati, Ola Gutzeit, Donald E. Ingber   +4 more
wiley   +1 more source

Novel dual-pathogen multi-epitope mRNA vaccine development for Brucella melitensis and Mycobacterium tuberculosis in silico approach.

PLoS ONE
Brucellosis and Tuberculosis, both of which are contagious diseases, have presented significant challenges to global public health security in recent years. Delayed treatment can exacerbate the conditions, jeopardizing patient lives.
Yuejie Zhu, Juan Shi, Quan Wang, Yun Zhu, Min Li, Tingting Tian, Huidong Shi, Kaiyu Shang, Zhengwei Yin, Fengbo Zhang   +9 more
doaj   +1 more source

Designing a Novel Multi-epitope Peptide Vaccine Against Pathogenic Shigella spp. Based Immunoinformatics Approaches [PDF]

, 2018
Ibrahim Farhani, Navid Nezafat, Shirin Mahmoodi   +2 more
openalex   +1 more source

Immunoinformatics-based design of a multi-epitope vaccine for Marburg virus

Journal of Biomolecular Structure and Dynamics
Marburg viruses (MARV) are negative-stranded RNA viruses belonging to filoviridae family. This virus causes severe haemorrhagic fever in humans and non-human primates, with a high fatality rate. Currently, there are no vaccines or drugs have been approved to induce productive immunity or control viral infection.
Thangamariappan, Esakkimuthu, Sivakumar, Praseetha, Marimuthu, Shakti Chandra Vadhana, Kunjiappan, Selvaraj, Sundar, Krishnan   +4 more
openaire   +1 more source

N‐ to C‐Glycoside Rearrangement of Uridine 5′‐Phosphate in Two Enzymatic Steps for the Production of Pseudouridine 5′‐Phosphate

Biotechnology and Bioengineering, EarlyView.
The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer, Franziska Guld, Bernd Nidetzky   +2 more
wiley   +1 more source

Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics

Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023
Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar, Md Anzarul Haque, Rakez Kayed   +2 more
wiley   +1 more source

Designing a multi-epitope subunit vaccine against Orf virus using molecular docking and molecular dynamics

Virulence
Orf virus (ORFV) is an acute contact, epitheliotropic, zoonotic, and double-stranded DNA virus that causes significant economic losses in the livestock industry.
Feng Pang, Qinqin Long, Shaobo Liang
doaj   +1 more source

Identification and characterisation of conserved epitopes of E. ruminantium that activate Th1 CD4+ T cells: Towards the development of a multi-epitope vaccine [PDF]

, 2019
N. Thema, Selaelo Ivy Tshilwane, Alri Pretorius, Lê Văn Sơn, Rae Marvin Smith, H.C. Steyn, Junita Liebenberg, Mirinda Van Kleef   +7 more
openalex   +1 more source