Results 161 to 170 of about 79,223 (384)

Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan‐Coronavirus Vaccine Development

Advanced Science, EarlyView.
Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang, Kanella M. Cohen, Liqiang Chen, Xiaowo Kang, Chang Liu, Megan E. Demouth, Wenxia Jiang, Alexander R. Maldeney, Rong Tong, Zunlong Ke, Kartik Chandran, Wei Luo, Qian Yin   +12 more
wiley   +1 more source

Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis

Frontiers in Immunology
BackgroundUveitis, characterized by intraocular inflammation, poses significant clinical challenges, often leading to vision impairment or blindness. Herpes Simplex Virus type 1 (HSV-1) is a major cause of virus-induced uveitis. This study aims to design
He Cao, Zhi Cao, Yue Han, Jing Shan
doaj   +1 more source

Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes [PDF]

, 2005
Fariba Karamloo, Peter Schmid‐Grendelmeier, Fatimah Kussebi, Mübeccel Akdiş, Maria Salagianni, Barbara R. von Beust, Andrea Reimers, Judith Zumkehr, Л. С. Солдатова, Zora Housley-Markovic, Ulrich Müller, Thomas M. Kündig, D.M. Kemeny, Michael D. Spangfort, Kurt Blaser, Cezmi A. Akdiş   +15 more
openalex   +1 more source

Design of a Novel Multi-Epitope Vaccine Against Echinococcus granulosus in Immunoinformatics

, 2021
Mingkai Yu, Yuejie Zhu, Yujiao Li, Zhiqiang Chen, Tong Sha, Zhiwei Li, Fengbo Zhang, Jianbing Ding   +7 more
openalex   +1 more source

Immunoinformatics design of a multi-epitope vaccine for Chlamydia trachomatis major outer membrane proteins

Scientific Reports
Chlamydia trachomatis (CT) remains a significant infectious cause of blindness and sexually transmitted infections worldwide. The objective and novelty of this study lie in using different serovars of CT to design a broad-spectrum multi-epitope vaccine ...
Seema Shetty, Swagatika Dash, Avinash Kumar, Shashidhar Vishwanath, S. Kini, Angela Brand   +5 more
semanticscholar   +1 more source

Rapid Decentralized Prostate Cancer Risk Stratification by Portable Liquid Biopsy Analysis within a Clinical Biosensor Validation Framework

Advanced Science, EarlyView.
In this work, we showcased two significant scientific advances in (i) developing a portable biosensor technology for rapid decentralized prostate cancer urinary biomarker testing and reporting, with superior performance to current clinical testing practice; and (ii) proposing a clinical validation framework (for our biosensor development) which can be ...
Kevin M. Koo, Grant Phillips, Sriganesh Srihari, Áine Farrell, Binny Jaradi, Kira J. Fitzpatrick, John W. Yaxley, Hemamali Samaratunga, Paul N. Mainwaring, Ke‐lin Ru, Darren J. Korbie, Scott A. Tomlins, Matthew J. Roberts, Robert A. Gardiner, Matt Trau   +14 more
wiley   +1 more source

Design and Production of a Multiepitope Construct Derived From Hepatitis E Virus Capsid Protein [PDF]

, 2015
The aim of this study was to design a high density multiepitope protein, which can be a promising multiepitope vaccine candidate against Hepatitis E virus (HEV). Initially, conserved and antigenic helper T-lymphocyte (HTL) epitopes in the HEV capsid
Farshadpour, Fatemeh, Makvandi, Manoochehr, Taherkhani, Reza   +2 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Patent Landscape of Helminth Vaccines and Related Technologies [PDF]

, 2013
Executive Summary This report focuses on patent landscape analysis of technologies related to vaccines targeting parasitic worms, also known as helminths.
Burke, Rayna, Cavicchi, Jon R., Kowalski, Stanley P., Michaud-King, Jillian, Schroeder, John   +4 more
core   +1 more source

Construction of an aerolysin-based multi-epitope vaccine against Aeromonas hydrophila: an in silico machine learning and artificial intelligence-supported approach

Frontiers in Immunology
Aeromonas hydrophila, a gram-negative coccobacillus bacterium, can cause various infections in humans, including septic arthritis, diarrhea (traveler’s diarrhea), gastroenteritis, skin and wound infections, meningitis, fulminating septicemia ...
Abdullah S. Alawam, M. S. Alwethaynani
semanticscholar   +1 more source