Results 261 to 270 of about 36,032 (319)

Formation of a β‐Endorphin Corona Mitigates Alzheimer's Amyloidogenesis

Small, EarlyView.
This study revealed the molecular mechanism of exercise‐induced β‐endorphin in suppressing the toxicity of Alzheimer's Aβ in vitro, in vivo and in silico. Abstract Senile plaques, comprised of nanosized aggregates of amyloid‐β (Aβ) peptides in the brain, are a pathological hallmark of Alzheimer's disease (AD).
Yunxiang Sun, Nicholas Andrikopoulos, Guofang Zhang, Yuying Liu, Xiufang Liang, Dongjie Li, Xiaoman Suo, Yue Wang, Yuhuan Li, Chuang Wang, Yang Li, Pu Chun Ke, Feng Ding   +12 more
wiley   +1 more source

Immunoinformatics design of a multi-epitope vaccine for Chlamydia trachomatis major outer membrane proteins. [PDF]

Sci Rep
Shetty S, Dash S, Kumar A, Vishwanath S, Kini SG, Brand A.   +5 more
europepmc   +1 more source

Dynamic Liposome Sensing Platform to Wirelessly Ensure Nucleic Acid Encapsulation via Non‐Contact Perception

Small, EarlyView.
Inspired by the Ampullae of Lorenzini in elasmobranch fish, a biomimetic electroreceptor platform is developed using an electret layer‐coated single‐walled carbon nanotube thin‐film transistor (eSWCNT‐TFT). This platform enables non‐contact, label‐free, and real‐time monitoring of DNA encapsulation efficiency in liposome droplets by detecting net ...
Younsu Jung, Jinhwa Park, Seonghun Shin, Sunghee Kim, Bijendra Bishow Maskey, Kiran Shrestha, Jianfu Ding, Thi Thuy Vy Tran, Patrick R. L. Malenfant, Jinkee Lee, Jong‐Sun Kang, Gyoujin Cho   +11 more
wiley   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Characterising Dissolution Dynamics of Engineered Nanomaterials: Advances in Analytical Techniques and Safety‐by‐Design

Small, EarlyView.
The perspective highlights how advanced analytical and computational tools—from batch tests and isotope labeling to in situ Electron Microscopy and Artificial IntelligenceI/Machine Learning—enable a deeper understanding of Engineered nanomaterial dissolution. These insights are crucial for controlling, regulating, and leveraging dissolution dynamics to
Swaroop Chakraborty, Eugenia Valsami‐Jones, Superb K. Misra   +2 more
wiley   +1 more source

The Internal Nanostructure of Lipid Nanoparticles Influences Their Diverse Cellular Uptake Pathways

Small, EarlyView.
Lipid nanoparticles are vital for drug delivery, but their cellular interactions remain unclear. This study shows that non‐lamellar lyotropic liquid crystalline nanoparticles (LLCNPs) ‐ including cubosomes, hexosomes, and micellar cubosomes ‐ preferentially use passive pathways like membrane fusion, bypassing endocytic recycling faced by lamellar ...
Sue Lyn Yap, Brendan Dyett, Alison J. Hobro, Han Nguyen, Nicholas I. Smith, Calum J. Drummond, Charlotte E. Conn, Nhiem Tran   +7 more
wiley   +1 more source

Development of a multi-epitope vaccine candidate to combat SARS-CoV-2 and dengue virus co-infection through an immunoinformatic approach. [PDF]

Front Immunol
Mandal S, Chanu WP, Natarajaseenivasan K.   +2 more
europepmc   +1 more source

Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma [PDF]

, 2019
Artyomov, Maxim N., Bender, Diane, Campian, Jian L., Chicoine, Michael R., Dacey, Ralph G., Dunn, Gavin P., Fritsch, Edward F., Gillanders, William E., Huang, Jiayi, Johanns, Tanner M., Kobayashi, Dale K., Liu, Connor J., Mardis, Elaine R., Miller, Christopher A., Perrin, Richard J., Schreiber, Robert D.   +15 more
core   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source