Results 91 to 100 of about 1,665,992 (319)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Experiments with multi-view multi-instance learning for supervised image classification

, 2011
In this paper we empirically investigate the benefits of multi-view multi-instance (MVMI) learning for supervised image classification. In multi-instance learning, examples for learning contain bags of feature vectors and thus data from different views ...
Mayo, Michael, Frank, Eibe
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

MF-SRGAN: A Super-Resolution Generative Adversarial Network for Multi-Focus Image Fusion [PDF]

International Journal of Mathematical, Engineering and Management Sciences
In computational imaging, multi-focus image fusion is a critical process that aims to produce a single image that covers all-in-focus areas from numerous partially focused input images.
Shatabdi Basu, Sunita Singhal, Dilbag Singh   +2 more
doaj   +1 more source

Multi-variate image analysis for detection of biomedical anomalies [PDF]

Multi-modal images are commonly used in the field of medicine for anomaly detection, for example CT/MRI images for tumour detection. Recently, thermal imaging has demonstrated its potential for detection of anomalies (e.g., water stress, disease) in ...
Raza, Shan-e-Ahmed
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Image fusion for dynamic contrast enhanced magnetic resonance imaging

, 2004
Twellmann T, Saalbach A, Gerstung O, Leach MO, Nattkemper TW. Image fusion for dynamic contrast enhanced magnetic resonance imaging. Biomed Eng Online. 2004;3(1): 35.BACKGROUND: Multivariate imaging techniques such as dynamic contrast-enhanced magnetic ...
Nattkemper, Tim Wilhelm ; https://orcid.org/, Nattkemper Tim W, Saalbach, A, Olaf Gerstung, Gerstung, O., Leach, M.O., Twellmann Thorsten, Twellmann, Thorsten, Nattkemper, TW, Axel Saalbach, Tim W Nattkemper, Leach, Martin O, Gerstung Olaf, Twellmann, T Thorsten, Thorsten Twellmann, Gerstung, Olaf, Saalbach Axel, Saalbach, Axel, Leach Martin O, Gerstung, O, Nattkemper, T.W., Martin O Leach, Saalbach, A., Twellmann, T.   +23 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MFFW: A new dataset for multi-focus image fusion

CoRR, 2020
Multi-focus image fusion (MFF) is a fundamental task in the field of computational photography. Current methods have achieved significant performance improvement. It is found that current methods are evaluated on simulated image sets or Lytro dataset. Recently, a growing number of researchers pay attention to defocus spread effect, a phenomenon of real-
Shuang Xu, Xiaoli Wei, Chunxia Zhang 0002, Junmin Liu, Jiangshe Zhang 0001   +4 more
openaire   +2 more sources

Multiple image view synthesis for free viewpoint video applications [PDF]

, 2005
Interactive audio-visual (AV) applications such as free viewpoint video (FVV) aim to enable unrestricted spatio-temporal navigation within multiple camera environments.
O'Connor, Noel E., N. O'Connor, Cooke, Eddie, E. Cooke, O\u27Connor, Noel E.   +4 more
core   +1 more source