Results 111 to 120 of about 18,640,676 (284)

Multi-Scale Visual Attention Deep Convolutional Neural Network for Multi-Focus Image Fusion

open access: yesIEEE Access, 2019
To realize the multi-focus image fusion task, an end-to-end deep convolutional neural network (DCNN) model that produces the final fused image directly from the source images is presented in this paper.
Rui Lai   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Multi-focus image fusion using maximum symmetric surround saliency detection

open access: yes, 2021
In digital photography, two or more objects of a scene cannot be focused at the same time. If we focus one object, we may lose information about other objects and vice versa.
Bavirisetti, Durga Prasad   +1 more
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

A pixel based multi-focus image fusion method

open access: yes, 2014
The lenses used in computer vision systems by nature provide limited depth of field, so digital cameras are incapable of acquiring an all-in-focus image of objects at varying distances in a scene. To obtain an all-in-focus image of such scenes from their
ASLANTAŞ, Veysel, TOPRAK, Ahmet Nusret
core   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Supporting Focus and Context Awareness in 3D Modeling Using Multi-Layered Displays [PDF]

open access: yes, 2013
Although advances in computer technology over the past few decades have made it possible to create and render highly realistic 3D models these days, the process of creating these models has remained largely unchanged over the years.
Mohd Yusof, Azmi
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

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