Results 111 to 120 of about 1,665,992 (319)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Multi-focus Image Fusion Using Curvelet Transform [PDF]

Proceedings of the 2nd International Symposium on Computer, Communication, Control and Automation, 2013
Curvelet transform is a new muiti-scale geometic analysis, which has the characteristics of anisotropy. It is more suitable for the analysis of image curve edge characteristics than wavelet. Thus, in this paper it is applied to multi-focus image fusion, and used fusion rules that suitable for the characteristics of multi-focus image fusion.
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Multi-Focus Image Fusion Based on Dual-Channel Rybak Neural Network and Consistency Verification in NSCT Domain

Fractal and Fractional
In multi-focus image fusion, accurately detecting and extracting focused regions remains a key challenge. Some existing methods suffer from misjudgment of focus areas, resulting in incorrect focus information or the unintended retention of blurred ...
Ming Lv, Sensen Song, Zhenhong Jia, Liangliang Li, Hongbing Ma   +4 more
doaj   +1 more source

Multi-focus Image Fusion Using an Effective Discrete Wavelet Transform Based Algorithm

Measurement Science Review, 2014
In this paper, by considering the main objective of multi-focus image fusion and the physical meaning of wavelet coefficients, a discrete wavelet transform (DWT) based fusion technique with a novel coefficients selection algorithm is presented. After the
Yang Yong, Huang Shuying, Gao Junfeng, Qian Zhongsheng   +3 more
doaj   +1 more source

Fine-grained multi-focus image fusion based on edge features. [PDF]

Sci Rep, 2023
Tian B, Yang L, Dang J.
europepmc   +1 more source

Strategies for image visualisation and browsing

, 2010
PhDThe exploration of large information spaces has remained a challenging task even though the proliferation of database management systems and the state-of-the art retrieval algorithms is becoming pervasive.
Janjusevic, Tijana
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A Review on Multi-Focus Image Fusion

, 2019
Image fusion is a process to collect the information of the images of the same scene from the different images with a focus on different objects. The Multi-focus image performs a vital role in image process and visual applications.
Bindu, Dr. Meenu Manchanda, Dr. Sandeep Tayal, Dr. Ankit Bansal
core