Results 101 to 110 of about 1,665,992 (319)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Construction of All-in-Focus Images Assisted by Depth Sensing

Sensors, 2019
Multi-focus image fusion is a technique for obtaining an all-in-focus image in which all objects are in focus to extend the limited depth of field (DoF) of an imaging system.
Hang Liu, Hengyu Li, Jun Luo, Shaorong Xie, Yu Sun   +4 more
doaj   +1 more source

Multi-focus image fusion using maximum symmetric surround saliency detection

, 2021
In digital photography, two or more objects of a scene cannot be focused at the same time. If we focus one object, we may lose information about other objects and vice versa.
Bavirisetti, Durga Prasad, Dhuli, Ravindra   +1 more
core  

Hybrid image representation methods for automatic image annotation: a survey [PDF]

, 2012
In most automatic image annotation systems, images are represented with low level features using either global methods or local methods. In global methods, the entire image is used as a unit.
Oukid, Saliha, Bechkoum, Kamal, S. Oukid, Bouyerbou, Hafidha, Benblidia, Nadjia, N. Benblidia, H. Bouyerbou, K. Bechkoum   +7 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A pixel based multi-focus image fusion method

, 2014
The lenses used in computer vision systems by nature provide limited depth of field, so digital cameras are incapable of acquiring an all-in-focus image of objects at varying distances in a scene. To obtain an all-in-focus image of such scenes from their
ASLANTAŞ, Veysel, TOPRAK, Ahmet Nusret
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Inter-Image Pixel Shuffling for Multi-focus Image Fusion

CoRR
Multi-focus image fusion aims to combine multiple partially focused images into a single all-in-focus image. Although deep learning has shown promise in this task, its effectiveness is often limited by the scarcity of suitable training data. This paper introduces Inter-image Pixel Shuffling (IPS), a novel method that allows neural networks to learn ...
Huangxing Lin, Rongrong Ma, Cheng Wang
openaire   +2 more sources

Multi-focus image fusing based on non-negative matrix factorization [PDF]

, 2007
Multi focus image fusion is a process of obtaining a new all in focus merged image from two or more partially defocused images of the same scene and same imaging condition. The merged image includes the information of the original images and improves the
Zhong Chen, Cong-bo Cai, Dong, J. Y., Chen, Z., Cai, C. B., Le Xu, 陈忠, Ji-yang Dong, Xu, L.   +8 more
core   +1 more source