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HSP70 Multi-Functionality in Cancer [PDF]

open access: yesCells, 2020
The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor ...
Zarema Albakova   +4 more
doaj   +5 more sources

Protein multi-functionality: introduction [PDF]

open access: yesCellular and Molecular Life Sciences, 2019
The five articles in this multi-author review in CMLS provide examples of multi-functionality of proteins belonging to several families. Distinct structural features of proteins suggesting multi-functionality are emphasized: intrinsically disordered elements that can "mold" themselves to fit various binding partners, as well as short linear motifs ...
Vsevolod V Gurevich
exaly   +4 more sources

HSP90 multi-functionality in cancer [PDF]

open access: yesFrontiers in Immunology
The 90-kDa heat shock proteins (HSP90s) are molecular chaperones essential for folding, unfolding, degradation and activity of a wide range of client proteins. HSP90s and their cognate co-chaperones are subject to various post-translational modifications,
Zarema Albakova, Zarema Albakova
doaj   +4 more sources

Centrin-Deleted Leishmania donovani Parasites Help CD4+ T Cells to Acquire Th1 Phenotype and Multi-Functionality Through Downregulation of CD200–CD200R Immune Inhibitory Axis [PDF]

open access: yesFrontiers in Immunology, 2018
The protozoan parasite Leishmania has evolved several strategies to undermine host defense mechanisms by inducing Th2-type adaptive immunity and suppressing effector functions of Th1 phenotype.
Rakesh K. Singh   +7 more
doaj   +2 more sources

Core microbiota drive multi-functionality of the soil microbiome in the Cinnamomum camphora coppice planting [PDF]

open access: yesBMC Microbiology
Background Cinnamomum camphora (L.) Presl (C. camphora) is an evergreen broad-leaved tree cultivated in subtropical China. The use of C. camphora as clonal cuttings for coppice management has become popular recently.
Luyuan Sun   +5 more
doaj   +2 more sources

Biodiversity and ecosystem multi-functionality: observed relationships in smallholder fallows in western Kenya. [PDF]

open access: yesPLoS ONE, 2012
Recent studies indicate that species richness can enhance the ability of plant assemblages to support multiple ecosystem functions. To understand how and when ecosystem services depend on biodiversity, it is valuable to expand beyond experimental ...
Jason Sircely, Shahid Naeem
doaj   +2 more sources

Multilayered Functional Triboelectric Polymers for Self-Powered Wearable Applications: A Review

open access: yesMicromachines, 2023
Multifunctional wearable devices detect electric signals responsive to various biological stimuli and monitor present body motions or conditions, necessitating flexible materials with high sensitivity and sustainable operation.
Minsoo P. Kim
doaj   +1 more source

Endowing Orthopedic Implants’ Antibacterial, Antioxidation, and Osteogenesis Properties Through a Composite Coating of Nano-Hydroxyapatite, Tannic Acid, and Lysozyme

open access: yesFrontiers in Bioengineering and Biotechnology, 2021
There is a substantial global market for orthopedic implants, but these implants still face the problem of a high failure rate in the short and long term after implantation due to the complex physiological conditions in the body.
Guofeng Wang   +3 more
doaj   +1 more source

Farmers’ Markets in Africa – A Sustainable Opportunity [PDF]

open access: yesAfrican Journal of Hospitality, Tourism and Leisure, 2022
The traditional farmers’ market has provided visitors with the opportunity to purchase fresh produce directly from the farmer. More recently, farmers’ markets have become the focal point in many communities and offer a wide range of products and ...
Hugh Bartis, Cornelis Oberholzer
doaj   +1 more source

Rurality and discourse: From the Spanish case to the Cantabrian case [PDF]

open access: yesAntropólogos Iberoamericanos en Red, 2012
The European Union reform of the Common Agricultural Policy (CAP) in 1992, in accordance to what has been called multifunctionality of rural environments, has considered as its most ambitious goals the preservation of the rural landscape and natural ...
Eloy Gómez-Pellón
doaj   +1 more source

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