Results 131 to 140 of about 630,412 (304)

Screening of multi deep learning-based de novo molecular generation models and their application for specific target molecular generation

Scientific Reports
Traditional virtual screening methods need to explore expanse and vast chemical spaces and need to be based on existing chemical libraries. With the development of deep learning techniques for the de novo generation of molecules, also known as inverse ...
Yishu Wang, Mengyao Guo, Xiaomin Chen, Dongmei Ai   +3 more
doaj   +1 more source

Multi focus acoustic field generation using Dammann gratings for phased array transducers

Results in Physics
Phased array transducers can shape acoustic fields for versatile manipulation; however, generating multiple focal points typically involves complex optimization.
Tatsuki Fushimi, Yusuke Koroyasu
doaj   +1 more source

The effect of radiation on the long term productivity of a plant based CELSS [PDF]

Mutations occur at a higher rate in space than under terrestrial conditions, primarily due to an increase in radiation levels. These mutations may effect the productivity of plants found in a controlled ecological life support system (CELSS).
Lake, B. H., Thompson, B. G.
core   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Generation of High‐Resolution Water Surface Slopes From Multi‐Mission Satellite Altimetry

Water Resources Research
For nearly three decades, satellite radar altimetry has provided measurements of the water surface elevation (WSE) of rivers. These observations can be used to calculate the water surface slope (WSS), which is an essential parameter for estimating flow ...
C. Schwatke, M. Halicki, D. Scherer
doaj   +1 more source

A multi-generational community

, 2017
This master thesis work consists of the study and the design of a potential multi-generational district in the city of Tampere, Finland. In fact, it focuses on the advantages and the importance of living in a mixed generation district. Developed in three main parts, this work begins with an introduction to the recent problematic of an aging population
openaire   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

DiffMC‐Gen: A Dual Denoising Diffusion Model for Multi‐Conditional Molecular Generation

Advanced Science
The precise and efficient design of potential drug molecules with diverse physicochemical properties has long been a critical challenge. In recent years, the emergence of various deep learning‐based de novo molecular generation algorithms offered new ...
Yuwei Yang, Shukai Gu, Bo Liu, Xiaoqing Gong, Ruiqiang Lu, Jiayue Qiu, Xiaojun Yao, Huanxiang Liu   +7 more
doaj   +1 more source