Results 91 to 100 of about 16,062,156 (297)

Types of Multi-Level Governance [PDF]

The reallocation of authority upwards, downwards, and sideways from central states hasdrawn attention from a growing number of scholars in the social sciences.
Liesbet Hooghe, Gary Marks
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Prelnc2: A prediction tool for lncRNAs with enhanced multi-level features of RNAs. [PDF]

PLoS One, 2023
Gao H, Gao P, Ye N.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Unveiling the mechanics of micro-LPBF manufactured hierarchical composites: a novel FE2-nested homogenisation approach

Virtual and Physical Prototyping
Multi-level periodicity is a ubiquitous structural feature of natural composites. Conventional homogenisation techniques can effectively address the mechanism of uniform periodic structures, while encountering challenges in efficiently characterising the
Tianyu Gao, Kai Liu, Qingping Ma, Junhao Ding, Zongxin Hu, Kai Wei, Xu Song, Zhendong Li, Zhonggang Wang   +8 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

MFTR-Net: A Multi-Level Features Network with Targeted Regularization for Large-Scale Point Cloud Classification. [PDF]

Sensors (Basel), 2023
Liu R, Zhang Z, Dai L, Zhang G, Sun B.
europepmc   +1 more source

Learning Multi-Level Features for Improved 3D Reconstruction

IEICE Transactions on Information and Systems, 2023
Fairuz Safwan Mahad, Masakazu Iwamura, Koichi Kise   +2 more
openaire   +2 more sources

Environmental governance: Participatory, multi-level - and effective? [PDF]

Current international and European Union environmental policies increasingly promote collaborative and participatory decision-making on appropriate and multiple governance levels as a means to attain more sustainable policies and a more effective and ...
Fritsch, Oliver, Newig, Jens
core