Results 71 to 80 of about 16,062,156 (297)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Multiscale attention-over-attention network for retinal disease recognition in OCT radiology images

Frontiers in Medicine
Retinal disease recognition using Optical Coherence Tomography (OCT) images plays a pivotal role in the early diagnosis and treatment of conditions.
Abdulmajeed M. Alenezi, Daniyah A. Aloqalaa, Sushil Kumar Singh, Raqinah Alrabiah, Shabana Habib, Muhammad Islam, Yousef Ibrahim Daradkeh   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Chinese Medical Named Entity Recognition Integrating Multi-Level Granular Features [PDF]

Jisuanji gongcheng
Chinese medical Named Entity Recognition (NER) aims to identify entities with specific meanings from medical texts, such as diseases, drugs, symptoms, and anatomical parts.
DAI Zinan, ZHANG Jie, CHEN Chongchong, CHEN Zhangyi, CHEN Fulong
doaj   +1 more source

Structured Multi-Level Feature Interaction Identification [PDF]

, 1997
Features are an established means of adding non-geometric information and extra geometric semantics to conventional CAD systems. It has been already realised that although feature-based modelling is necessary for the next generation of integrated design and manufacturing systems, inherent feature interactions pose a difficulty in representing and ...
M. S. Hounsell, K. Case
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Aggregating multi-scale contextual features from multiple stages for semantic image segmentation

Connection Science, 2021
Semantic segmentation plays a vital role in image understanding. Recent studies have attempted to achieve precise pixel-level classification by using deep networks that provide hierarchical features.
Dingchao Jiang, Hua Qu, Jihong Zhao, Jianlong Zhao, Meng-Yen Hsieh   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Reference-Based Multi-Level Features Fusion Deblurring Network for Optical Remote Sensing Images

, 2022
Blind image deblurring is a long-standing challenge in remote sensing image restoration tasks. It aims to recover a latent sharp image from a blurry image while the blur kernel is unknown.
Jiayi Guo, Zhiyuan Li, Yueting Zhang, Jie Li, Yirong Wu   +4 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source