Results 61 to 70 of about 16,062,156 (297)

EU Transport Infrastructure Policy, New Institutionalism and Types of Multi-Level Governance: The Case of Vienna [PDF]

, 2009
Multi-level Governance (MLG) fundamentally challenges a state-centric, intergovernmentalist understanding of EU policy-making, emphasising the nonhierarchical, interconnected and multi-actor nature of contemporary governing.
Awesti, Anil
core  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Large-scale tissue histopathology image segmentation based on feature pyramid

EURASIP Journal on Image and Video Processing, 2018
Histopathology image analysis is a gold standard for cancer recognition and diagnosis. But typical problems with histopathology images that hamper automatic analysis include complex clinical features, insufficient training data, and large size of a ...
Pinle Qin, Jun Chen, Jianchao Zeng, Rui Chai, Lifang Wang   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Multi-level Feature Learning for Contrastive Multi-view Clustering

2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 2022
Multi-view clustering can explore common semantics from multiple views and has attracted increasing attention. However, existing works punish multiple objectives in the same feature space, where they ignore the conflict between learning consistent common semantics and reconstructing inconsistent view-private information. In this paper, we propose a new
Jie Xu 0044, Huayi Tang, Yazhou Ren 0001, Liang Peng, Xiaofeng Zhu 0001, Lifang He 0001   +5 more
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Harnessing Multiple Level Features to Improve Segmentation Performance of Deep Neural Network: A Case Study in Magnetic Resonance Imaging of Nasopharyngeal Cancer

IEEE Access
The lesion area of cancer presents complex physiological structures, posing significant challenges for accurate segmentation, which is required in radiotherapy or chemo-radiotherapy.
Rongzhi Mao, Liangxu Xie, Xiaohua Lu, Jialu Pei, Xiaojun Xu, Shan Chang   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source