Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Agent-Based Modeling Framework for Electric Vehicle Adoption Transition in Indonesia
World Electric Vehicle Journal, 2021 Currently, the adoption of electric vehicles (EV) draws much attention, as the environmental issue of reducing carbon emission is increasing worldwide. However, different countries face different challenges during this transition, particularly developing
Dita Novizayanti +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Critical Review on Community-Shared Solar—Advantages, Challenges, and Future Directions
Energies, 2023 In the last few years, many innovative solutions have been presented to address the climate change crisis. One of the innovative solutions is the participation of community members in the collective production of solar electricity instead of individual ...
Nima Narjabadifam +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Strategic Energy Transition in Higher Education: A Multi-Level Perspective on Renewable Energy Innovation at Universitas Diponegoro [PDF]
E3S Web of ConferencesEnergy transition has become a global imperative in response to climate change, energy security, and sustainable development goals. As centers of knowledge and innovation, universities have a crucial role to play in leading and modeling this transition ...
Bramiana Chely Novia +4 more
doaj +1 more source
National Systems of Innovation and Entrepreneurship: In Search of a Missing Link [PDF]
, 2007 The literature on national systems of innovation (NIS) has neglected the issue of entrepreneurship because of several incompatibilities between the two notions.
Radosevic, S
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Emergent coopetition from a sensemaking perspective: A multi-level analysis [PDF]
, 2017 This article considers the development of coopetitive sensemaking across multiple levels of analysis, which include individual (micro), organizational/inter-organizational (meso), and network/ecosystem (macro).
Lindgreen, Adam +2 more
core +4 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source