Results 71 to 80 of about 919,462 (268)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Five-axis coordinated multi-material simultaneous 3D printing for geometrically conformal multi-material structures

Virtual and Physical Prototyping
The integration of functional devices with mechanical structures is crucial for developing compact and high-performance mechatronic systems. However, fabricating geometrically conformal multi-material structures and devices on curved surfaces remains a ...
Changyong Liu, Chen Li, Xiangxin Liu, Qimiao Chen, Zhiyuan Liu, Zhangwei Chen, Lei Zhang   +6 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Additive Manufacturing of Dual-Zone Personalized Shin Guards

Journal of Manufacturing and Materials Processing
Additive manufacturing enables the fabrication of personalized protective equipment with locally tailored mechanical properties. In this work, a low-cost scan-to-print workflow is proposed for the fused filament fabrication (FFF) of personalized dual ...
Savvas Koltsakidis, Mathis Moullec, Georgios Moysiadis, Dimitrios Tzetzis   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Multi-material three dimensional printed models for simulation of bronchoscopy

BMC Medical Education, 2019
Background Bronchoscopy involves exploration of a three-dimensional (3D) bronchial tree environment using just two-dimensional (2D) images, visual cues and haptic feedback.
Brian Han Khai Ho, Cecilia Jiayu Chen, Gerald Jit Shen Tan, Wai Yee Yeong, Heang Kuan Joel Tan, Albert Yick Hou Lim, Michael Alan Ferenczi, Sreenivasulu Reddy Mogali   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

MULTI-MATERIAL 3D PRINTER EXTRUDER CONCEPT

Journal of Industrial Design and Engineering Graphics, 2018
Since the RepRap (Replicating rapid prototyper) project, FDM (Fused Deposition Modeling) 3D printing technology has come a long way. As the machine evolves so does the range of materials we can print with and the applications in which we can use them. 3D
Daniel Pascale, Ionel Simion
doaj  

In situ multi-material μCLIP for fabricating Fe3O4/HEMA-based magnetic miniature devices with large deformation

Virtual and Physical Prototyping
Micro-continuous liquid interface production (μCLIP) enables high-speed and high-precision fabrication of magnetic microstructures by reducing resin residence time and suppressing particle settling.
Zhiyuan Huang, Jianyuan Liang, Guangbin Shao, Bin Peng, Hongmingze He, Yingdan Wu, Longqiu Li   +6 more
doaj   +1 more source

Functionally Graded SS 316L to Ni-Based Structures Produced by 3D Plasma Metal Deposition

Metals, 2019
In this investigation, the fabrication of functionally graded structures of SS316L to Ni-based alloys were studied, using the novel technique 3D plasma metal deposition.
Johnnatan Rodriguez, Kevin Hoefer, Andre Haelsig, Peter Mayr   +3 more
doaj   +1 more source