Results 41 to 50 of about 88,926 (217)

Epidemiological Study of Childhood Idiopathic Epilepsy from 1990 to 2021 at Global, Regional, and National Scales

Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Objective: To address the long-term impact of childhood idiopathic epilepsy on health and families, and to provide epidemiological evidence for developing effective prevention and treatment strategies, this study aimed to explore the trends in incidence,
Li Wang, MM, Lei Tang, MM, Ji Zhang, MM, Ye Li, MM, Feng Zhang, MD, Qiaoling Tang, MB, Siyuan Ma, MB, Ran Liu, MB, Xiangbin Zhang, MM, Sai Wang, MD, Yupeng Zhang, MM, Lei Chen, MM, Junyi Ma, MM, Xuelun Zou, MM, Tianxing Yao, MM, Rongmei Tang, MM, Yexiang Yi, MB, Yi Zeng, PhD, Duolao Wang, PhD, Le Zhang, MD   +19 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Design of a robot system for reorienting and assembling irregular parts

International Journal of Advanced Robotic Systems
The design of a robot system for assembling numerous parts, including screws, washers, nuts, and other irregular parts, is important in manufacturing. Although a robot can flexibly manipulate various parts with the aid of vision and force sensors, some ...
Jianhua Su, Liancheng Shen, Zongyu Peng, Xiaoyi Qu   +3 more
doaj   +1 more source

Mutual Complementarity: Multi-Modal Enhancement Semantic Learning for Micro-Video Scene Recognition

IEEE Access, 2020
Scene recognition is one of the hot topics in micro-video understanding, where multi-modal information is commonly used due to its efficient representation ability.
Jie Guo, Xiushan Nie, Yilong Yin
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Neural-linguistic analysis for Alzheimer’s detection: A deep learning approach informed by cognitive neuroscience

NeuroImage
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that disrupts cognitive function across multiple domains, particularly affecting language networks and speech production pathways in the brain.
Jianhui Lv, Shalli Rani, Keqin Li, Ning Liu   +3 more
doaj   +1 more source

Computer-Supported Modelling of Multi modal Transportation Networks Rationalization

Promet (Zagreb), 2007
This paper deals with issues of shaping and functioning ofcomputer programs in the modelling and solving of multimoda Itransportation network problems. A methodology of an integrateduse of a programming language for mathematical modellingis defined, as ...
Ratko Zelenika, Slavomir Vukmirović, Hilmija Mujić   +2 more
doaj   +1 more source