Results 71 to 80 of about 3,839,669 (256)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Multi-modal Multi-kernel Graph Learning for Autism Prediction and Biomarker Discovery [PDF]

Graph learning-based multi-modal integration and classification is one of the most challenging tasks for disease prediction. To effectively offset the negative impact among modalities in the process of multi-modal integration and heterogeneous ...
Kuang, Hulin, Liu, Fei, Lin, Hanhe; id_orcid, Pan, Shirui, Wu, Xusheng, Liu, Jin, Pan, Yi, Mao, Junbin, Xie, Shan, Lin, Hanhe   +9 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Design of a robot system for reorienting and assembling irregular parts

International Journal of Advanced Robotic Systems
The design of a robot system for assembling numerous parts, including screws, washers, nuts, and other irregular parts, is important in manufacturing. Although a robot can flexibly manipulate various parts with the aid of vision and force sensors, some ...
Jianhua Su, Liancheng Shen, Zongyu Peng, Xiaoyi Qu   +3 more
doaj   +1 more source

Mutual Complementarity: Multi-Modal Enhancement Semantic Learning for Micro-Video Scene Recognition

IEEE Access, 2020
Scene recognition is one of the hot topics in micro-video understanding, where multi-modal information is commonly used due to its efficient representation ability.
Jie Guo, Xiushan Nie, Yilong Yin
doaj   +1 more source

An architecture for a multi-modal Web Browser

, 2002
In this work we propose an architecture for handling multi-modal browsing through the synchronization of HTML and VoiceXML documents. A client uses a traditional Web brower to interpret HTML documents.
C. Rognoni, Azzini, Ivano, Nardelli, Luca, Orlandi, Marco, Toni Giorgino   +4 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Neural-linguistic analysis for Alzheimer’s detection: A deep learning approach informed by cognitive neuroscience

NeuroImage
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that disrupts cognitive function across multiple domains, particularly affecting language networks and speech production pathways in the brain.
Jianhui Lv, Shalli Rani, Keqin Li, Ning Liu   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Multi Modal Aptitude Detection System for Smart Office

IEEE Access, 2019
Smart offices are places that aim to provide a favorable, interactive, and healthy environment for the employees. As a result, their working efficiency is enhanced.
Mohammad Tehseen, Huma Javed, Amjad Mehmood, Muhammad Amin, Ishtiaq Hussain, Bilal Jan   +5 more
doaj   +1 more source