Results 81 to 90 of about 3,839,669 (256)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Research and prospect of standard for biometric multi-modal fusion used with mobile devices

open access: yesDianxin kexue, 2021
Aiming at the problem of inconsistent biometric multi-modal fusion technology framework for mobile devices and lack of standards, a unified technical framework of multi-modal fusion standards was proposed.Firstly, the current status of standardization ...
Guanchen LIN, Zhifei WANG
doaj   +2 more sources

Leveraging intra-modal and inter-modal interaction for multi-modal entity alignment [PDF]

open access: yes
Multi-modal entity alignment (MMEA) aims to identify equivalent entity pairs across different multi-modal knowledge graphs (MMKGs). Existing approaches focus on how to better encode and aggregate information from different modalities.
Li, Ru   +4 more
core   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

An EEG-based multi-scale hybrid attention and squeeze network for objective taste assessment

open access: yesFuture Foods
Taste perception is central to flavor experiences. Electroencephalography (EEG) signals carry rich information about taste perception. Because these neural data are independent of verbal reports and bypassing conscious filtering, EEG holds promise as a ...
Tianyi Yang   +9 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Guided Hash Algorithm for Information Semantic Retrieval in Multimedia Environment

open access: yesIEEE Access
With technological progress, how to efficiently process and retrieve large amounts of multi-modal multimedia data has become a challenge. Although multi-modal hash algorithms have been applied in this field, their performance potential has not been fully
Xiaojuan Zhao
doaj   +1 more source

Multi-Modal Distance Metric Learning

open access: yes, 2018
Multi-modal data is dramatically increasing with the fast growth of social media. Learning a good distance measure for data with multiple modalities is of vital importance for many applications, including retrieval, clustering, classification and ...
Pengtao Xie (5364230)   +1 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

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