Results 71 to 80 of about 12,816,466 (238)

Study on Mix Proportion Optimization and Microstructure of Coal-Based Solid Waste (CSW) Backfill Material Based on Multi-Objective Decision-Making Model. [PDF]

Materials (Basel), 2022
Zhao X, Yang K, He X, Wei Z, Yu X, Zhang J.   +5 more
europepmc   +1 more source

A Distributed Agent-based Decision Support for Cloud Brokering [PDF]

, 2014
In goal oriented problems, decision-making is a crucial aspect aiming at enhancing the ability to make decisions by full autonomous, or supervised software agents.
Amato, Alba, Venticinque, Salvatore
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Improved dynamic programming method for solving multi-objective and multi-stage decision-making problems

Scientific Reports
Multi-objective and multi-stage decision-making problems require balancing multiple objectives at each stage and making optimal decision in multi-dimensional control variables, where the commonly used intelligent optimization algorithms suffer from low ...
Zhihao Liang, Kegang Zhao, Kunyang He, Yanwei Liu   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Deep Collaborative Innovation Product Decision-Making Model Based on Multi-Objective Optimization

IEEE Access
With the advancement of societal living standards, the cultural and creative industry (CCI) facing the challenge of balancing user demands, market demands, and the preservation of traditional culture.
Kunrong Zhao, Xuerui Li, Xinggang Hou, Yehui Zhang   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Intelligent decision-making for TBM tunnelling control parameters using multi-objective optimization

Journal of Rock Mechanics and Geotechnical Engineering
In tunnel construction, tunnel boring machine (TBM) tunnelling typically relies on manual experience with sub-optimal control parameters, which can easily lead to inefficiency and high costs.
Shaokang Hou, Yaoru Liu, Jialin Yu, Rujiu Zhang, Li Cheng, Chenfeng Gao   +5 more
doaj   +1 more source

Multi-objective bandit algorithms with Chebyshev scalarization. [PDF]

, 2023
In this paper we analyze several alternatives for Chebyshev scalarization in multi-objective bandit problems. The alternatives are evaluated on a reference bi-objective benchmark problem of Pareto frontier approximation.
Martín-Albo, Sergio, Pérez-de-la-Cruz-Molina, José Luis, Mandow-Andaluz, Lorenzo   +2 more
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source