Results 51 to 60 of about 12,816,466 (238)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Application of TOPSIS and AHP in the Multi-Objective Decision-Making Problems
MATEC Web of Conferences, 2018 The problems of multi-objective decision making are analysed and studied. In order to solve its optimization problems, the basic principles and application steps of TOPSIS and AHP are introduced in this paper.
Wang Yihan
doaj +1 more source
State-of-the-art review on multi-criteria decision-making in the transport sector
Journal of Traffic and Transportation Engineering (English ed. Online), 2020 Consistent decision-making requires a structured and systematic evaluation of advantages and disadvantages of different choice possibilities. For transport projects, policies or policy measures, and transport options evaluation, various multi-criteria ...
George Yannis +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Decision-Making of Underwater Cooperative Confrontation Based on MODPSO
Sensors, 2019 This paper proposes a multi-objective decision-making model for underwater countermeasures based on a multi-objective decision theory and solves it using the multi-objective discrete particle swarm optimization (MODPSO) algorithm.
Na Wei, Mingyong Liu, Weibin Cheng
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Multi Objective Decision Making for Impregnability of Needle Mat Using Design of Experiment Technique and Respond Surface Methodology [PDF]
Journal of Applied Research on Industrial Engineering, 2016 One of the main problems in production process of composite curly sheet process is long time duration of impregnability of needle mat to resin operation and high costs of this operation.
Hamidreza Jafari, Alborz Hajikhani
doaj +1 more source