Results 41 to 50 of about 845,538 (282)

Multi-Objective Simultaneous Optimistic Optimization [PDF]

Information Sciences, 2018
Optimistic methods have been applied with success to single-objective optimization. Here, we attempt to bridge the gap between optimistic methods and multi-objective optimization. In particular, this paper is concerned with solving black-box multi-objective problems given a finite number of function evaluations and proposes an optimistic approach ...
Abdullah Al-Dujaili, S. Suresh
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Multi-Objective Predictive Taxi Dispatch via Network Flow Optimization

, 2020
In this paper, we discuss a large-scale fleet management problem in a multi-objective setting. We aim to seek a receding horizon taxi dispatch solution that serves as many ride requests as possible while minimizing the cost of relocating vehicles.
Huh, Subin, Kim, Beomjun, Kim, Jeongho, Yang, Insoon, You, Seungil   +4 more
core   +1 more source

Optimal Microgrid Topology Design and Siting of Distributed Generation Sources Using a Multi-Objective Substrate Layer Coral Reefs Optimization Algorithm [PDF]

, 2018
n this work, a problem of optimal placement of renewable generation and topology design for a Microgrid (MG) is tackled. The problem consists of determining the MG nodes where renewable energy generators must be optimally located and also the ...
Camacho-Gómez, Carlos, Del Ser, Javier, Fernández, Juan, Jiménez-Fernández, Silvia, Mallol-Poyato, Ricardo, Portilla-Figueras, Antonio, Salcedo-Sanz, Sancho   +6 more
core   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Multi-objective global optimization for hydrologic models [PDF]

, 1998
The development of automated (computer-based) calibration methods has focused mainly on the selection of a single-objective measure of the distance between the model-simulated output and the data and the selection of an automatic optimization algorithm ...
Gupta, HV, Sorooshian, S, Yapo, PO
core   +1 more source

Multi-objective parametric query optimization [PDF]

Proceedings of the VLDB Endowment, 2014
Classical query optimization compares query plans according to one cost metric and associates each plan with a constant cost value. In this paper, we introduce the Multi-Objective Parametric Query Optimization (MPQ) problem where query plans are compared according to multiple cost metrics and the cost of a given plan according to a given metric is ...
Immanuel Trummer, Christoph Koch
openaire   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Multi objective elk herd optimization for efficient structural design

Scientific Reports
This research presents an advancement of the Elk Herd Optimization targeting specific real-world multi-objective optimization problems, this algorithm is stated as the multi-objective Elk Herd Optimization (MOEHO).
Pinank Patel, Divya Adalja, Nikunj Mashru, Pradeep Jangir, Arpita, Reena Jangid, Gulothungan G, Mohammad Khishe   +7 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source