Results 31 to 40 of about 9,969,039 (243)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Multi objective elk herd optimization for efficient structural design
Scientific ReportsThis research presents an advancement of the Elk Herd Optimization targeting specific real-world multi-objective optimization problems, this algorithm is stated as the multi-objective Elk Herd Optimization (MOEHO).
Pinank Patel +7 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
MOMPA: Multi-objective marine predator algorithm for solving multi-objective optimization problems
, 2021 This paper proposes a new multi-objective algorithm, called Multi-Objective Marine-Predator Algorithm (MOMPA), dependent on elitist non-dominated sorting and crowding distance mechanism.
Jangir, Pradeep +7 more
core +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Journal of Machine Engineering, 2021 This paper presents a study to ensure the minimum value of Ra and Rz, and the maximum value of MRR when external cylindrical grinding by the PSI. The experiments performed according to the orthogonal Taguchi L9 matrix with the input parameters were ...
Dung Hoang Tien +3 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Multi-Objective Optimization using Artificial Intelligence Techniques
, 2020 This book focuses on the most well-regarded and recent nature-inspired algorithms capable of solving optimization problems with multiple objectives. Firstly, it provides preliminaries and essential definitions in multi-objective problems and different ...
Dong, Jin Song, Mirjalili, Seyedali
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source