Results 91 to 100 of about 132,617 (313)

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Multi-objective worst case optimization by means of evolutionary algorithms [PDF]

open access: yes
Many real-world optimization problems are subject to uncertainty. A possible goal is then to find a solution which is robust in the sense that it has the best worst-case performance over all possible scenarios.
Avigad, Gideon   +2 more
core  

A multi-objective fuzzy programming model for coordinate operations of a supply chain with uncertain demands [PDF]

open access: yes, 2012
The coordinate operating process of a supply chain is considered. The supply chain is consisting of a manufacturer, a supplier and several customers, the semi-finished products of the supplier are raw materials of the manufacturer, demands of customers ...
Zhang Y(张毅)   +2 more
core  

Multi-objective Genetic Programming for Explainable Reinforcement Learning

open access: yes, 2022
Deep reinforcement learning has met noticeable successes recently for a wide range of control problems. However, this is typically based on thousands of weights and non-linearities, making solutions complex, not easily reproducible, uninterpretable and heavy.
Videau, Mathurin   +3 more
openaire   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

"Maximizing Conservation and In-Kind Cost Share: Applying Goal Programming to Forest Protection" [PDF]

open access: yes
This research evaluates the potential gains in benefits from using Goal Programming to preserve forestland. Two- and three-dimensional Goal Programming models are developed and applied to data from applicants to the U.S.
Jacob R. Fooks, Kent D. Messer
core  

Multi-objective Tabu Search 2: first technical report [PDF]

open access: yes, 2015
The purpose of this document is to describe Multi-Objective Tabu Search 2 (MOTS2), which is a native mutli-objective optimiser. It has been developed to tackle a variety of real-world problems of engineering interest. The design and implementation are
Tsotskas, Christos   +2 more
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

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