Results 71 to 80 of about 8,593,463 (294)

Inverse optimization for multi-objective linear programming

Optimization Letters, 2019
This paper generalizes inverse optimization for multi-objective linear programming where we are looking for the least problem modifications to make a given feasible solution a weak efficient solution. This is a natural extension of inverse optimization for single-objective linear programming with regular "optimality" replaced by the "Pareto optimality".
Mostafa Naghavi, Ali Asghar Foroughi, Masoud Zarepisheh   +2 more
openaire   +3 more sources

Multi-Objective region-Aware optimization of parallel programs [PDF]

Parallel Computing, 2019
Auto-tuning has become increasingly popular for optimizing non-functional parameters of parallel programs. The typically large search space requires sophisticated techniques to find well-performing parameter values in a reasonable amount of time. Different parts of a program often perform best with different parameter values.
Durillo, Juan J., Gschwandtner, Philipp, Kofler, Klaus, Fahringer, Thomas   +3 more
openaire   +2 more sources

An Interactive Fuzzy Satisficing Method for Fuzzy Random Multiobjective 0-1 Programming Problems through Probability Maximization Using Possibility [PDF]

, 2009
In this paper, we focus on multiobjective 0-1 programming problems under the situation where stochastic uncertainty and vagueness exist at the same time.
Matsui, Takeshi, Sakawa, Masatoshi, Kato, Kosuke, Hontani, Takehisa   +3 more
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Resolution of the linear fractional goal programming problem

Rect@, 2010
This work deals with the resolution of the goal programming problem with linear fraccional criteria. The main difficulty of these problems is the non-linear constraints of the mathematical programming models that have to be solved.
Hernández, Mónica, Caballero, Rafael
doaj  

A Multi-Objective Optimization Approach for Multi-Head Beam-Type Placement Machines [PDF]

This paper addresses a highly challenging scheduling problem in the field of printed circuit board (PCB) assembly systems using Surface Mounting Devices (SMD).
Ashayeri, J., Hamedi, M., Torabi, S.A.
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Multi‐objective interval type‐2 fuzzy linear programming problem with vagueness in coefficient

CAAI Transactions on Intelligence Technology
One of the most widely used fuzzy linear programming models is the multi‐objective interval type‐2 fuzzy linear programming (IT2FLP) model, which is of particular importance due to the simultaneous integration of multiple criteria and objectives in a ...
Shokouh Sargolzaei, Hassan Mishmast Nehi
doaj   +1 more source

A Two-Stage Multi-objective Programming Model to Improve the Reliability of Solution

International Journal of Computational Intelligence Systems, 2020
Randomness is a common uncertainty encountered in practical multi-objectives decision-making. But it is always a challenge for decision-makers to process randomness in multi-objective programming problems.
Chenxia Jin, Fachao Li, Kaixin Feng, Yunfeng Guo   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source