Results 61 to 70 of about 46,244 (265)

A Synthesizing Effect-Based Solution Method for Stochastic Rough Multi-objective Programming Problems [PDF]

International Journal of Computational Intelligence Systems, 2014
Multi-objective programming with uncertain information has been widely applied in modeling of industrial produce and logistic distribution problems. Usually the expectation value model and chance-constrained model as solution models are used to deal with
Lei Zhou, Guoshan Zhang, Fachao Li
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Resolution of the linear fractional goal programming problem

Rect@, 2010
This work deals with the resolution of the goal programming problem with linear fraccional criteria. The main difficulty of these problems is the non-linear constraints of the mathematical programming models that have to be solved.
Hernández, Mónica, Caballero, Rafael
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multi‐objective interval type‐2 fuzzy linear programming problem with vagueness in coefficient

CAAI Transactions on Intelligence Technology
One of the most widely used fuzzy linear programming models is the multi‐objective interval type‐2 fuzzy linear programming (IT2FLP) model, which is of particular importance due to the simultaneous integration of multiple criteria and objectives in a ...
Shokouh Sargolzaei, Hassan Mishmast Nehi
doaj   +1 more source

A Two-Stage Multi-objective Programming Model to Improve the Reliability of Solution

International Journal of Computational Intelligence Systems, 2020
Randomness is a common uncertainty encountered in practical multi-objectives decision-making. But it is always a challenge for decision-makers to process randomness in multi-objective programming problems.
Chenxia Jin, Fachao Li, Kaixin Feng, Yunfeng Guo   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Taylor Series Approximation to Solve Neutrosophic Multiobjective Programming Problem [PDF]

Neutrosophic Sets and Systems, 2015
In this paper, Taylor series is used to solve neutrosophic multi-objective programming problem (NMOPP). In the proposed approach, the truth membership, Indeterminacy membership, falsity membership functions associated with each objective of multi ...
Ibrahim M. Hezam, Mohamed Abdel-Baset, Florentin Smarandache   +2 more
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source