Results 61 to 70 of about 132,617 (313)

Modeling Multi-Objective, Multi-Product and Multi-Period Supplier Selection Problem Considering Stochastic Demand [PDF]

مدیریت تولید و عملیات, 2018
In this paper, a multi-objective, multi-period and multi-product mixed integer programming model ‎for the supplier selection and quota allocation problem under an all-unit quantity discount policy, ‎constrained storage space and stochastic demand is ...
Mehdi Seifbarghy, Foruzan Naseri
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Multi-objective probabilistic fractional programming problem involving two parameters Cauchy distribution

Mathematical Modelling and Analysis, 2019
The paper presents the solution methodology of a multi-objective probabilistic fractional programming problem, where the parameters of the right hand side constraints follow Cauchy distribution. The proposed mathematical model can not be solved directly.
Srikumar Acharya, Berhanu Belay, Rajashree Mishra   +2 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Optimization Library for Interactive Multi-Criteria Optimization Tasks [PDF]

, 2012
The commercial library Optimization 2.1 for interactive multi-criteria optimization tasks has been released along with Dymola 2013. The library offers several numerical optimization algorithms for solving different kinds of optimization tasks.
Pfeiffer, Andreas, Andreas Pfeiffer
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

An objective comparison of languages for teaching introductory programming [PDF]

, 2006
The question of which language to use in introductory programming has been cause for protracted debate, often based on emotive opinions. Several studies on the benefits of individual languages or comparisons between two languages have been conducted, but
Mannila, Linda, Michael de Raadt, de Raadt, Michael, Linda Mannila   +3 more
core   +1 more source

DEA common set of weights based on a multi objective Fractional Programming

International Journal of Industrial Engineering and Production Research, 2014
Data envelopment analysis operates as a tool for appraising the relative efficiency of a set of homogenous decision making units. This methodology is applied widely in different contexts.
Seyed Hossein Razavi Hajiagha, Shide Sadat Hashemi, Hannan Amoozad Mahdiraji   +2 more
doaj  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Multi-Objective Genetic Programming with Redundancy-Regulations for Automatic Construction of Image Feature Extractors [PDF]

, 2010
We propose a new multi-objective genetic programming (MOGP) for automatic construction of image feature extraction programs (FEPs). The proposed method was originated from a well known multi-objective evolutionary algorithm (MOEA), i.e., NSGA-II. The key
KUDO, Hiroaki, WATCHAREERUETAI, Ukrit, TAKEUCHI, Yoshinori, MATSUMOTO, Tetsuya, OHNISHI, Noboru   +4 more
core