Results 51 to 60 of about 46,244 (265)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Multi-objective probabilistic fractional programming problem involving two parameters Cauchy distribution

Mathematical Modelling and Analysis, 2019
The paper presents the solution methodology of a multi-objective probabilistic fractional programming problem, where the parameters of the right hand side constraints follow Cauchy distribution. The proposed mathematical model can not be solved directly.
Srikumar Acharya, Berhanu Belay, Rajashree Mishra   +2 more
doaj   +1 more source

On the Use of Semantics in Multi-objective Genetic Programming [PDF]

, 2016
Research on semantics in Genetic Programming (GP) has increased dramatically over the last number of years. Results in this area clearly indicate that its use in GP can considerably increase GP performance. Motivated by these results, this paper investigates for the first time the use of Semantics in Muti-Objective GP, within the well-known NSGA-II ...
Galván-López, Edgar, Mezura-Montes, Efrén, Ait Elhara, Ouassim, Schoenauer, Marc   +3 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

DEA common set of weights based on a multi objective Fractional Programming

International Journal of Industrial Engineering and Production Research, 2014
Data envelopment analysis operates as a tool for appraising the relative efficiency of a set of homogenous decision making units. This methodology is applied widely in different contexts.
Seyed Hossein Razavi Hajiagha, Shide Sadat Hashemi, Hannan Amoozad Mahdiraji   +2 more
doaj  

Multi-Objective Gene Expression Programming for Clustering

Information Technology And Control, 2012
This paper proposes a multi-objective gene expression programming for clustering (MGEPC), which could automatically determine the number of clusters and the appropriate partitioning from the data set. The clustering algebraic operations of gene expression programming are extended first.
Yifei Zheng, Lixin Jia, Hui Cao 0003
openaire   +1 more source

Multi-Objective region-Aware optimization of parallel programs [PDF]

Parallel Computing, 2019
Auto-tuning has become increasingly popular for optimizing non-functional parameters of parallel programs. The typically large search space requires sophisticated techniques to find well-performing parameter values in a reasonable amount of time. Different parts of a program often perform best with different parameter values.
Durillo, Juan J., Gschwandtner, Philipp, Kofler, Klaus, Fahringer, Thomas   +3 more
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A pythagorean hesitant fuzzy programming approach and its application to multi objective reliability optimization problem [PDF]

Yugoslav Journal of Operations Research
Decision-making problems can often be effectively solved using traditional optimization methods that have a clearly defined configuration. However, in real-world scenarios, decision-makers frequently encounter doubt or hesitation, making it challenging ...
Jana Swarup, Islam Sahidul
doaj   +1 more source