Results 81 to 90 of about 46,244 (265)

On Supportedness in Multi‐Objective Integer Linear Programming

open access: yesJournal of Multi-Criteria Decision Analysis
ABSTRACT This paper addresses an inconsistency in various definitions of supported non‐dominated points within multi‐objective integer linear optimization problems (MOILPs). MOILP problems are known to contain supported and unsupported non‐dominated points, with the latter typically outnumbering the former ...
David Könen, Michael Stiglmayr
openaire   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Multi-Objective Integer Programming: An Improved Recursive Algorithm

open access: yesJournal of Optimization Theory and Applications, 2013
11 pages, 6 tables; v2: added more details and a computational ...
Melih Ozlen   +2 more
openaire   +7 more sources

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

OPTIMASI PERENCANAAN PRODUKSI DENGAN METODE GOAL PROGRAMMING

open access: yesJurnal Ilmiah Teknik Industri, 2007
PT. NM memiliki tujuan yang ingin dicapai, antara lain memaksimalkan pendapatan penjualan, meminimalkan biaya produksi, memaksimalkan jam kerja reguler, meminimalkan jam lembur memaksimalkan utilitas mesin, dan meminimalkan biaya kualitas.
Muchlison Anis   +2 more
doaj   +1 more source

Computational complexity analysis of multi-objective genetic programming [PDF]

open access: yesProceedings of the 14th annual conference on Genetic and evolutionary computation, 2012
A conference version has been accepted for GECCO ...
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

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